Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

logPow > 6.2 at 22 °C (experimental)
logPow = 8.4 (QSAR)

Key value for chemical safety assessment

Log Kow (Log Pow):
8.4

Additional information

The octanol-water partition coefficient, log Pow, of the substance 2 -Hexyl-2 '-hydroxy-5 'methyldecananilide (AF-654), was investigated using an HPLC method according to OECD Guideline 117 and EU Method A.8. Since the substance appeared outside the validity range, only the lower limit of 6.2 could be derived. In order to obtain a value for the chemical safety assessment, the Rekker calculation method was applied, resulting in the log Pow value of 8.4. The two estimations are consistent.