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EC number: 429-790-9 | CAS number: 137281-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 December 1994 to 15 Dec 1994
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- Investigations described are insufficiently documented and cannot be subsumed under OECD 402. Therefore a reliability score of 3 is assigned to this study as there is insufficient data in the final report such as sex of animals and lack of COA (certificate of analysis)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Testing conducted to assess the short-term toxicity of the test material in rabbits when administered by a single dermal dose, using three test animals.
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid
- EC Number:
- 429-790-9
- EC Name:
- 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid
- Cas Number:
- 137281-39-1
- Molecular formula:
- Hill formula: C15 H14 N4 O3 CAS formula: C15 H14 N4 O3
- IUPAC Name:
- 4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)benzoic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- Compound 202723
Storage condition of test material: room temperature
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Outside vendor
- Housing: Stainless steel cages
- Diet: ad libitum supply of 'Purina Certified Rabbit Chow #5322' laboratory animal feed
- Water: ad libitum supply of water
- Acclimation period: Minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Humidity: 25 -60% which exceeded the range (40-70%) specified in the protocol had no apparent impact on the outcome of this study
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Back of the animal
- % coverage: 10% of the animal's body surface area
- Type of wrap if used:4 ply gauze dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Using gauze moistened with distilled water
- Time after start of exposure: 24 -hours
TEST MATERIAL
- Amount(s) applied: A level of 1000mg/kg body weight to approximately 10% of the animal's body surface area which was calculated using the formula presented below.
- For solids, paste formed: no - Duration of exposure:
- 24 hour
- Doses:
- 1000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Twice daily on the day of administration (day 0) then once daily thereafter (days 1 -14), any signs of irritation were assessed using the Draize dermal evaluation criteria
- Body Weights: Prior to dosing on day 0 and on days 7 and 14
- Necropsy of survivors performed: no - Statistics:
- None performed
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: median lethal dose
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0 of 3
- Clinical signs:
- very slight erythema in 3/3 animals on day 1-2 of occurrence; very slight edema for 1/3 animals on day 1 of occurrence; ancillary irritation on the trunk outside the test site for 2/3 animlas on day 1-5 of occurrence.
- Body weight:
- Not available
- Gross pathology:
- Not available
Any other information on results incl. tables
Table 1 - Summary of clinical observations made after dermal administration of a single dose of 1000mg/kg of Compound 202723
Slight abnormalities | Animals Affected No. Observed/No. Dosed |
Day(s) of Occurrence |
Mortality | 0/3 | - |
Very slight erythema | 3/3 | 1 -2 |
Very slight edema | 1/3 | 1 |
Ancillary irritation on the truck outside the test site | 2/3 | 1 -5 |
The calculated primary irritation index was 0.78 which classifies this dose level as a slight irritant to the dermal tissue of the rabbit.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- Based on the results, the test substance does not require any classification according to EU standards. No mortality or toxicity observed at 1000mg/kg, the highest dose tested. The criteria for classification are not fulfilled for dermal toxicity Categories 1 -3. Classification for Category 4 via application of substance criteria is not possible since acute toxicity test was not available between 1000mg/kg and 2000mg/kg.
- Executive summary:
Short term dermal toxicity of compound 202723 was investigated in 3 New Zealand white rabbits at a dose level of 1000mg/kg.
No mortalities occurred and animals were examined for signs of clinical abnormalities each day throughout the 14 day observation period. Very slight irritation, erythema and edema were observed. The calculated Primary Irritation Index was 0.78, which classifies this dose level as a slight irritant to the dermal tissue of the rabbit. Based on the results of this study, the acute dermal Median lethal dose (MLD) of compound 202723 was estimated to be greater than 1000mg/kg in the rabbit.
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