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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2021-02-08 to 2021-02-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- Column temperature: 25°C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC System Agilent 1100 series: HPLC pump G1311A, autosampler G1313A, column oven G1316A, degasser G1322A
- Type, material and dimension of analytical (guard) column: Stationary phase: Zorbax Eclipse XDB-CN, Agilent; Particle size: 3.5 pm, pore size: 80 µm; Material: stainless steel, dimensions: 100 mm x 4.6 mm, Serial No.: USBAB01223
- Detection system: variable wavelength detector G1314A (210 nm; 254 nm: calibration substances; 294 nm: test item)
- Flow rate: 0.6 mL/min.
MOBILE PHASES
- Type: Potassium dihydrogen phosphate buffer solution (0.05 mol/l)/ACN 45:55 % (v/v), pH = 7.4, isocratic elution
- Type: Citrat buffer solution (0.05 mol/l)/ACN 45:55 % (w/v), pH = 5.5, isocratic elution
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column - formamide
REFERENCE SUBSTANCES
- Identity: Acetanilide (CAS # 103-84-4); Atrazin (CAS # 1912-24-9); Triadimenol (CAS # 55219-65-3); Linuron (CAS # 330-55-2); Pyrazophos (CAS # 13457-18-6); Diclofop-methyl (CAS # 51338-27-3); 4,4' DDT (CAS # 50-29-3)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 µL ; 0.43 µg (pH 7.4); 0.30 µg (pH 5.5)
- Quantity of reference substances: 10 µL; Calibration substances: 0.96—1.11 µg
REPETITIONS
- Number of determinations: duplicate
EVALUATION
- Calculation of capacity factors k': refer to "Any other information on materials and methods incl. tables" below
- Calculation of retention times: refer to "Any other information on materials and methods incl. tables" below
- Determination of the log Koc value: refer to "Any other information on materials and methods incl. tables" below - Key result
- Type:
- Koc
- Value:
- ca. 2 512 dimensionless
- pH:
- 5.5
- Temp.:
- 25 °C
- Type:
- Koc
- Value:
- ca. 631 dimensionless
- pH:
- 7.4
- Temp.:
- 25 °C
- Type:
- log Koc
- Value:
- 2.8 dimensionless
- pH:
- 7.4
- Temp.:
- 25 °C
- Type:
- log Koc
- Value:
- 3.4 dimensionless
- pH:
- 5.5
- Temp.:
- 25 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The log Koc value of N-(4-((4-(3-phenyIureido)phenyI)suIfonyI)phenyI)benzenesuIfonamide at pH 7.4 (ionised form) was 2.8 (Koc = 631) and at pH 5.5 (Koc = 2512; non-ionised form) 3.4, respectively.
- Executive summary:
The adsorption coefficient (Koc) of N-(4-((4-(3-phenyIureido)phenyI)suIfonyI)phenyI)benzenesuIfonamide on soil and on sewage sludge was determined according to using high performance liquid chromatography (HPLC) as described in the European Commission Regulation (EC) No. 440/2008, method C. 19 and OECD 121 (2001).
The log Koc value of the test substance at pH 7.4 (ionised form) and at pH 5.5 (non-ionised form) was 2.8 and 3.4 (Koc: 631 and 2512), respectively.
Reference
Description of key information
The log Koc value of N-(4-((4-(3-phenyIureido)phenyI)suIfonyI)phenyI)benzenesuIfonamide at pH 7.4 (ionised form) was 2.8 (Koc = 631) and at pH 5.5 (Koc = 2512; non-ionised form) 3.4, respectively. The higher Koc value of 2512 is selected for risk assessment as a worst-case.
Key value for chemical safety assessment
- Koc at 20 °C:
- 2 512
Additional information
The test was performed according to the European Commission Regulation (EC) No. 440/2008, method C.19 and OECD 121 (2001).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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