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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Toxicokinetic Assessment of Lithium Nickel Potassium Oxide (KDLNO) Using Physico-Chemical Properties and Toxicological Study Data
- Remarks:
- See attached justification document with "Toxicokinetic Assessment of Lithium Nickel Potassium Oxide (KDLNO) Using Physico-Chemical Properties and Toxicological Study Data"
- Justification for type of information:
- See attached justification document with "Toxicokinetic Assessment of Lithium Nickel Potassium Oxide (KDLNO) Using Physico-Chemical Properties and Toxicological Study Data".
- Conclusions:
- Based upon the available data, the systemic absorption of the substance KDLNO is expected to
be negligible regardless of the route of exposure. Inhalation exposure is not expected under
normal use conditions based upon the particle size as manufactured and processed and life-cycle
information for the substance. The absence of systemic effects in the acute and repeated-dose
toxicity studies in rats indicate that absorption of the substance was very limited; effects were
limited to the tissues in direct contact with the test substance. Effects related to dissolved nickel
were not observed, even at the highest dose tested. In the unlikely event that the substance is
absorbed, KDLNO is expected to dissolve to the separate metal ions (nickel, potassium, and
lithium). The amounts of potassium and lithium in the substance are very low, so even if
absorbed, they cannot contribute more than a negligible quantity to the blood or other tissues.
All three ions should be excreted rapidly in urine.
Reference
Description of key information
Based upon the available data, the systemic absorption of the substance KDLNO is expected to
be negligible regardless of the route of exposure. Inhalation exposure is not expected under
normal use conditions based upon the particle size as manufactured and processed and life-cycle
information for the substance. The absence of systemic effects in the acute and repeated-dose
toxicity studies in rats indicate that absorption of the substance was very limited; effects were
limited to the tissues in direct contact with the test substance. Effects related to dissolved nickel
were not observed, even at the highest dose tested. In the unlikely event that the substance is
absorbed, KDLNO is expected to dissolve to the separate metal ions (nickel, potassium, and
lithium). The amounts of potassium and lithium in the substance are very low, so even if
absorbed, they cannot contribute more than a negligible quantity to the blood or other tissues.
All three ions should be excreted rapidly in urine.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.