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EC number: 411-950-4 | CAS number: 96562-58-2 DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl (R)-2-(4-hydroxyphenoxy)propionate
- EC Number:
- 411-950-4
- EC Name:
- Methyl (R)-2-(4-hydroxyphenoxy)propionate
- Cas Number:
- 96562-58-2
- Molecular formula:
- C10H12O4
- IUPAC Name:
- methyl (2R)-2-(4-hydroxyphenoxy)propanoate
- Test material form:
- solid
- Details on test material:
- - Appearance: Brown solid
- Storage conditions of test material: Refrigerator
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- CHBB: THOM (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females (if applicable) nulliparous and non-pregnant: Not specified
- Age at study initiation: Young adult animals
- Weight at study initiation: Animals of comparable weight between 150 and 300 g (± 20 % of the mean weight)
- Fasting period before study: Yes; the animals were given no feed for at least 16 hours before administration, but water was available ad libitum
- Housing: The animals were singly housed in stainless steel wire mesh cages. There was no bedding in the cages but sawdust was available in the waste trays.
- Diet: ad libitum
- Water: ad libitum access to tap water
- Acclimation period: At least one week
ENVIRONMENTAL CONDITIONS
- Temperature: 20 to 24 °C
- Humidity: 30 to 70 % (relative)
- Air changes: Not specified; the room was air conditioned
- Photoperiod: 12 hours of light/12 hours of darkness (06:00 to 18:00 light)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Remarks:
- DAB 9
- Details on oral exposure:
- DOSING SOLUTION
The test material was administered as an emulsion (application of cooled down test material preparation to body temperature).
The stability of the test material in olive oil DAB 9 over a time period of 4 hours was confirmed by analysis. A concentration control analysis was performed and values were found to be about 12 % higher than expected. Homogeneity of the preparation was provided by stirring and heating at about 70 °C.
VEHICLE
- Concentration in vehicle: 44 g/100 mL
- Justification for choice of vehicle: The test material was poorly soluble in water
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg - Doses:
- 2200 mg/kg of bodyweight
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual body weights were determined shortly before application (day 0), weekly thereafter and at the end of the study (before fasting period). Recording of signs and symptoms took place several times on the day of administration and at least once each workday for the individual animals. A check was made twice each workday and once on Saturdays, Sundays and on public holidays for general observations and for any dead or moribund animals.
- Necropsy of survivors performed: Yes. Necropsy with gross pathological examination was performed on the last day of the observation period, with withdrawal of food at least 16 hours before death with CO2.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- There were no mortalities observed.
- Clinical signs:
- other: There were no clinical signs observed for any of the animals throughout the study.
- Gross pathology:
- No pathology findings were noted in any of the animals.
Any other information on results incl. tables
Table 1. Individual body weights
Dose (mg/kg) |
Males |
Day 0 |
Day 7 |
Day 13 |
2200 |
Cage 949 |
185 |
257 |
281 |
Cage 950 |
187 |
263 |
288 |
|
Cage 951 |
185 |
250 |
282 |
|
Cage 952 |
191 |
250 |
278 |
|
Cage 953 |
190 |
244 |
266 |
|
Dose (mg/kg) |
Females |
Day 0 |
Day 7 |
Day 13 |
2200 |
Cage 954 |
180 |
212 |
217 |
Cage 955 |
182 |
213 |
227 |
|
Cage 956 |
183 |
213 |
225 |
|
Cage 957 |
183 |
212 |
227 |
|
Cage 958 |
179 |
198 |
212 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU criteria
- Conclusions:
- Under the conditions of this study, the LD50 was greater than 2200 mg/kg body weight (males and females).
- Executive summary:
A study was conducted to investigate the acute oral toxicity of the test material in accordance with the standardised guidelines OECD 401 and EU Method B.1 under GLP conditions.
A group of ten fasted animals (five males and five females) was given a single oral dose of the test material prepared in olive oil DAB 9 at a dose level of 2200 mg/kg of bodyweight by gavage. Over a 14 day observation period, the animals were monitored for mortality, signs of toxicity and body weight gain. At the end of the observation period animals were sacrificed and subjected to necropsy with gross pathological examination.
No mortality occurred and no signs of toxicity were noted at this dose level. The expected body weight gains were observed throughout the course of the study. No abnormalities were noted at necropsy.
Under the conditions of this study, the LD50 was greater than 2200 mg/kg body weight (males and females).
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