Registration Dossier
Registration Dossier
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EC number: 411-950-4 | CAS number: 96562-58-2 DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Under the conditions of this study, the 3-hour EC50 was > 100 mg/L for activated sludge.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 100 mg/L
Additional information
The potential of the test material to cause toxic effects to microorganisms was investigated in accordance with the standardised guideline OECD 209 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The effect on the respiration of activated sewage sludge was evaluated using a 3-hour static test. Microorganisms from a predominantly domestic source at a concentration of 1.6 g/L were exposed to the test material at concentrations of 0, 1, 3.16, 10, 31.6 and 100 mg/L in dechlorinated water. 3,5-Dichlorophenol was also used as reference. The oxygen consumption of the solutions was measured for approximately 10 minutes after an aeration of 3 hours. The EC50 was determined considering the oxygen consumption of the controls as 100 %.
The respiration rate of the test solution at the highest concentration (100 mg/L) was equivalent to the respiration rate of the first control (i.e. these rates were within 15 % of each other). Therefore, the oxygen consumption rate of the four other test solutions was not determined. As the validity criteria were met (difference between the two controls was below 15 % and the EC50 of 3,5-dichlorophenol was between 5 and 30 mg/L), the test was considered valid. The test material should be considered as non-toxic for the micro-organisms in a water treatment plant.
Under the conditions of this study, the 3-hour EC50 was > 100 mg/L for activated sludge.
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