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EC number: 200-836-8 | CAS number: 75-07-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test was based on the OECD Guidelines for Testing Chemicals (OECD, 1981) and the EEC Dangerous Substances Directive.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetaldehyde
- EC Number:
- 200-836-8
- EC Name:
- Acetaldehyde
- Cas Number:
- 75-07-0
- Molecular formula:
- C2H4O
- IUPAC Name:
- acetaldehyde
- Details on test material:
- 0.5 mL/patch
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- 1 hour and 4 hours
- Observation period:
- The results were assessed 1, 24, 48 and 72 hr and 7 days after removel of the patch.
- Number of animals:
- Six rabbits were used (three adults male and three adults female).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4 hr
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other:
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- test performed in 1984
- Irritation parameter:
- edema score
- Basis:
- other:
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- test performed in 1984
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The skin irritation/corrosion results showed that Acetaldeyde is not irritating to the rabbit skin after 4-hr exposure, using the semi-occlusive method, even after a 4-hr occlusive application the substance is "non-irritant.
- Executive summary:
The test was based on the OECD Guidelines for Testing Chemicals (OECD, 1981) and the EEC Dangerous Substances Directive.
The skin irritation/corrosion results showed that Acetaldeyde is not irritating to the rabbit skin after 4-hr exposure, using the semi-occlusive method. The semi-occlusive method is stongly advocated in the case of volatile substance.
Acetaldehyde is labelled as irritant in Annex I of the directive (EEC, 1967 and amendments), but the skin result, even after a 4 -hr occlusive application ("non-irritant"), suggest that the classification is mainly because of potential irritation to the eye and/or the respiratory tract. Therefore, the substance will be not classified as skin irritant according to EU Criteria.
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