Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 460-390-7 | CAS number: 26504-29-0
Endpoint summary
Administrative data
Description of key information
According to the maximization method of Magnusson and Kligman, DIBENZYL TRITHIOCARBONATE is considered as a moderate sensitizer
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The delayed contact hypersensivity of DIBENZYL TRITHIOCARBONATE was evaluated in Guinea pigs according to OECD N°406 guideline (Magnusson and Kligman test) (Ollivier, 2004d).
The induction phase has been realized both by intradermal route on day 0.1 (% in vehicle) and by cutaneous route on day 50 (%) in 2 groups of guinea pigs: 5 males and 5 females for control group and 10 males and 10 females for treated group. The challenge phase was realized on day 22 by cutaneous application of 25 % on the right flank (vehicle on the left flank); the cutaneous reactions were scored 24 and 48 hours after the challenge phase.
After the challenge application, a discrete erythema was observed in 2/10 animals of the control group, at the 24-hour reading only.
In the treated group, a discrete or moderate erythema, together with an oedema in one animal, was noted at the 24-hour reading in 17/20 and 2/20 animals, respectively. At the 48-hour reading, a discrete or moderate erythema, together with dryness of the skin in two animals, persisted in 7/20 and 2/20 animals, respectively. The persistent cutaneous reactions observed in 9/20 animals of the treated group were attributed to delayed contact hypersensitivity.
Under the experimental conditions of the maximization method of Magnusson and Kligman, DIBENZYL TRITHIOCARBONATE induces delayed contact hypersensitivity in 9/20 (45%) guinea pigs, and should therefore be considered as a moderate sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008, DIBENZYL TRITHIOCARBONATE must be classified as skin senzitizer (may cause an allergic skin reaction).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
