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EC number: 448-020-2
CAS number: -
Maximum concentration not causing irritating effects in preliminary test: 20 %
Signs of irritation during induction:
Test of primary irritation with different concentration of
the test sample was realised. The fixation time was 24
hours. One hour after removing bandage the sign of
irritation was observed. The highest concentration not
giving rise to irritating effects applied epicutaneously
was 20% sample in olive oil.
The signs of irritation observation during induction have
not been executed.
Evidence of sensitisation of each challenge concentration:
1st Challenge 24 hour:
In 48 hours after application seven animals had the positive
skin reactions: two of the animals had the middle
repletion and the mild oedema, five of the animals had the
mild or the dappled repletion and the mild or the very
In 72 hours after application the reaction was held over all
the previous reagents, the reaction was expressed as the
repletion, the oedema and the separating of skin surface
coats. For the animals numbered 28 and 30 the reaction was
held over the next 24 hours as the result of the allergic
The sensitivity and reliability control results of the test:
Applied substance - Benzocain (CAS No.94-09-7)
Intradermal induction exposition: 5% conc.in olive oil.
Epicutan exposition: 25% concentration in vaseline alba.
Challange concentration: 5% concentration in vaseline alba.
Test results : 60% positive dermal reaction. The test
reliability was confirmed.
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