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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- The ototoxic effect of boric acid solutions applied into the middle ear of guinea pigs.
- Author:
- Öztürkcan S, Dündar R, Katilmiş H, İlknur AE, Aktaş S & Haciömeroğlu S.
- Year:
- 2 009
- Bibliographic source:
- Eur. Arch. Otorhinolaryngol. 266: 663 - 667.
Materials and methods
- Type of study / information:
- The study analysed the ototoxic effects of boric acid solutions on 22 young guinea pigs.
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study analysed the ototoxic effects of boric acid solutions on 22 young guinea pigs. Auditory Brainstem Response (ABR) test was applied prior to adminsitration. A perforation was created on the tympanic membrane of the right ear and small gelfoam pieces were inserted into the perforation. Test solutions were administered for 10 days by means of a transcanal route. 15 days after insertion of the gelfoams they were removed and the ABR repeated.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- Molecular formula:
- H3BO3
- IUPAC Name:
- Boric acid
Constituent 1
Results and discussion
Any other information on results incl. tables
When the saline control group and the 4 % boric acid solution prepared with distilled water group were compared against the initial condition of both groups, a borderline significance was detected (P = 0.046; P = 0.046, respectively). When the ototoxic control (Gentamicine) and 4 % boric acid solution prepared with 70 % alcohol groups were compared against their initial conditions, statistically signifcant changes in the ABRs threshold was found (P = 0.026; P = 0.011, repectively). When the ototoxic control group was compared with the 4 % boric acid solution prepared with distilled water and with the saline group, a statistically significant toxic effect was found in the ototoxic control group ( P = 0.003; P = 0.001, respectively). When the Gentamicine group was compared with 4 % boric acid solution prepared with 70 % alcohol group, no significant difference in ototoxic effect was detected between the two groups (p = 0.128).
As a result of the comparison of the 4 % boric acid solution prepared with 70 % alcohol group with the saline group and the 4 % boric acid prepared with distilled water groups statistically significant effect in the 4 % boric acid solution prepared with 70 % alcohol was detected (P = 0.002 ; P = 0.000). No statistically significance was found in comparison of the saline and 4 % boric acid solution prepared with distilled water groups (P: 0.653). In the group where 4 % boric acid solutions prepared with 70 % alcohol statistically significant alterations in the test thresholds were detected.
Applicant's summary and conclusion
- Conclusions:
- The study analysed the ototoxic effects of boric acid solutions on 22 young guinea pigs. Prior to application of the boric acid solution under general anaesthesia an Auditory Brainstem Response (ABR) test was applied to the right ear of the guinea pigs. Following the test a performation was created on the tympanic membrane of the right ear of each guinea pig and small gelfoam pieces inserted into the perforated area. Test soluitons were administered to the middle ear for 10 days by means of a transcanal route. 15 days after inserting the gelfoams they were removed and the ABR test performed again. The ABRs were within the normal range before applications after hte application no singificant changes were deteced in the ABRs threshold in the saline group or the group administered boric acid and dstilled water solution. However, significant changes were detected in the ototoxic control group (Gentamicine) and boric acid and alcohol solution groups.
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