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EC number: 701-439-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-07-19 to 2012-08-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Version / remarks:
- 2001
- Deviations:
- yes
- Remarks:
- The 28-day test with a loading of 1 mg/L was conducted at pH 6 instead of 5.5
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2011-02-07
- Type of method:
- flask method
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 60.3 µg/L
- Element analysed:
- Cobalt
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 6
- Remarks on result:
- other: S.D.: ± 1.52 µg/L
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 101 µg/L
- Element analysed:
- Cobalt
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 6
- Remarks on result:
- other: S.D.: ± 3.81 µg/L
- Key result
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 138 µg/L
- Element analysed:
- Cobalt
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 28 d
- Test conditions:
- pH 6
- Remarks on result:
- other: S.D.: ± 6.36 µg/L
- Details on results:
- Temperature
The mean temperature recorded by the data logger from day 4 until day 28 is 21.0 ± 1.1 °C. The mean temperature recorded by the pH-meter during the complete study is 22.2 ± 0.2 °C. Therefore, the mean temperature is in agreement with the OECD guidance document 29.
pH
According to the guidance, the solution pH can be expected to remain constant (± 0.2 units) during most tests. The solution pH remained relatively constant during the 28 days in vessels containing the test item and in method blanks, pH ranged from of 5.7– 6.2.
Oxygen
Oxygen levels in all test vessels and 1 mg /L loadings were in the range recommended by the OECD Test Guidance 29 during the test: above 70 % of oxygen saturation at 8.5 mg/L (70 % of 8.5 mg/L = 6 mg/L).
Mass balance
After 12h of digestion with aqua regia, insoluble residues were not observed in any test vessel, indicating a complete dissolution of the test item. The recovery of cobalt was in the range of 93.1 – 98.0 %. - Conclusions:
- Under the described conditions of the transformation/dissolution test according to OECD series 28 with IPC-2013-006-01 (Olivine, cobalt silicate blue), the following dissolved cobalt concentrations were measured at the respective loading, solution pH and exposure:
- 1 mg/L loading at pH 6 after 7 days: 101 ± 3.81 µg/L cobalt
- 1 mg/L loading at pH 6 after 28 days: 138 ± 6.36 µg/L cobalt
Reference
Method validation summary (ICP-MS)
validation parameter | results | comment |
selectivity | similar data with at least two different isotopes for ICP-MS method | no interferences observed, measurements with best recoveries of reference material were used for calculation |
Linearity | applied calibration functions were linear | correlation factor at least 0.9994 |
limit of detection | 0.001 – 0.014 μg/L | |
limit of quantification | 0.004 – 0.042 μg/L | |
method blanks (total: 48 samples) | 12 samples < LOD 2 samples > LOD and < LOQ 34 samples > LOQ |
method blanks with Co levels >LOQ are below Co concentrations in test sample (at least by a factor of 332 lower) |
accuracy | mean recovery for CRM TMDA- 70 (285 μg Co/L, dilution factor 5): 108 ± 1.8 % (n = 2) | mid concentration range of samples (diluted 57 μg Co/L) |
accuracy | mean recovery for CRM TMDA- 70 (285 μg Co/L, dilution factor 2): 115 ± 5.2 % (n = 2) | high concentration range of samples (diluted 145 μg Co/L) |
accuracy | mean recovery for CRM TM-DWS.2 (64.4 μg Co/L, dilution factor 20): 103 ± 1.8 % (n = 8) | low concentration range of samples (diluted 3.22 μg Co/L) |
accuracy | mean recovery for CRM TM-DWS.2 (64.4 μg Co/L, dilution factor 5): 100 ± 0.3 % (n = 6) | mid concentration range of samples (diluted 12.9 μg Co/L) |
accuracy | mean recovery for CRM TM-DWS.2 (64.4 μg Co/L, dilution factor 2): 108 ± 0.3 % (n = 2) | mid concentration range of samples (diluted 32.2 μg Co/L) |
accuracy | mean recovery for CRM TM15.2 (15.1 μg Co/L, dilution factor 5): 105 ± 3.0 % (n = 14) | low concentration range of samples (diluted 3.02 μg Co/L) |
trueness | mean recovery for CPI recalibration standard (100 μg/L): 102 ± 3.7 % (n = 12) | high concentration range |
trueness | mean recovery for Merck IV recalibration standard (50 μg/L): 100 ± 2.1 % (n = 2) | mid concentration range |
trueness |
mean recovery for Merck IV recalibration standard (100 μg/L): 107 ± 0.4 % (n = 2) |
high concentration range |
trueness |
Recovery fortification samples: 103 – 115 % |
|
reproducibility |
mean recovery for CRM TMDA- 70 (285 μg Co/L, dilution factor 5): 108 ± 1.8 % (n = 2) |
mid concentration range of samples (diluted 57 μg Co/L) |
reproducibility |
mean recovery for CRM TMDA- 70 (285 μg Co/L, dilution factor 2): 115 ± 5.2 % (n = 2) |
high concentration range of samples (diluted 145 μg Co/L) |
reproducibility |
mean recovery for CRM TM-DWS.2 (64.4 μg Co/L, dilution factor 20): 103 ± 1.8 % (n = 8) |
low concentration range of samples (diluted 3.22 μg Co/L) |
reproducibility |
mean recovery for CRM TM-DWS.2 (64.4 μg Co/L, dilution factor 5): 100 ± 0.3 % (n = 6) |
mid concentration range of samples (diluted 12.9 μg Co/L) |
reproducibility |
mean recovery for CRM TM-DWS.2 (64.4 μg Co/L, dilution factor 2): 108 ± 0.3 % (n = 2) |
mid concentration range of samples (diluted 32.2 μg Co/L) |
reproducibility |
mean recovery for CRM TM15.2 (15.1 μg Co/L, dilution factor 5): 105 ± 3.0 % (n = 14) |
low concentration range of samples (diluted 3.02 μg Co/L) |
Measured dissolved Co concentrations (loading of 1 mg/L at pH 6)
sample | LOD [μg/L] | LOQ [μg/L] | mean Co conc. all vessels ± SD [μg/L] |
1, 2, 3 - 2h | 0.014 | 0.042 | 9.71 ± 1.05 |
1, 2, 3 - 6h | 0.014 | 0.042 | 25.5 ± 2.90 |
1, 2, 3 - 24h | 0.005 | 0.015 | 60.3 ± 1.52 |
1, 2, 3 - 96h | 0.005 | 0.015 | 87.2 ± 7.39 |
1, 2, 3 - 168h | 0.005 | 0.015 | 101 ± 3.81 |
1, 2, 3 - 336h | 0.005 | 0.015 | 117 ± 3.50 |
1, 2, 3 - 504h | 0.001 | 0.004 | 131 ± 8.38 |
1, 2, 3 - 672h | 0.001 | 0.004 | 138 ± 6.36 |
Test summary
Under the described conditions of this test with IPC-2013-006-01 (Olivine, cobalt silicate blue), the following dissolved concentrations were measured at the respective loading, exposure and solution pH:
1 mg/L loading at pH 6 after 7 days: Cobalt: 101 ± 3.81 µg/L
1 mg/L loading at pH 6 after 28 days: Cobalt: 138 ± 6.36 µg/L
The OECD Series 29 requires a limit of 20 % and 10 % for the between-vessel and within vessel variation, respectively.
The observed variations within the test flasks were in compliance with the guidance except for the within-vessel variations of vessel 1 and 2 (11.5 % and 12.3 %) after 2 h and vessel 2 (12.7 %) after 96 h. The observed variations between the test flasks over the experimental period were in the range of 2.5 – 11.4 %.
Description of key information
The solubility of Reaction mass of cobalt olivine and crystalline silicon dioxide is ~10 wt% at a 1mg/L loading.
Transformation/dissolution at a loading of 1 mg/L at pH 6, the pH that maximises dissolution, after 7 and 28 days resulted in dissolved cobalt concentrations of 101 µg Co/L and 138 µg Co/L, respectively. (Knopf, 2014).
The particle size of the tested sample (BET surface area 16 m2/g) is representative for the particle size on the market. Thus, the extent to which "Reaction mass of cobalt olivine and crystalline silicon dioxide" can produce soluble available ionic and other metal-bearing species in aqueous media is limited.
Key value for chemical safety assessment
Additional information
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