Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1969

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
No description of the guideline available
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylcyclohexanone
EC Number:
209-513-6
EC Name:
2-methylcyclohexanone
Cas Number:
583-60-8
Molecular formula:
C7H12O
IUPAC Name:
2-methylcyclohexan-1-one
Test material form:
liquid
Details on test material:
As received, undiluted, the sample was observed to be a free-flowing
clear liquid.

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
<= 1 637 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated value considering LD50 value reported in mL/Kg, converted to mg/Kg by considering density
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1.77 mL/kg bw
Based on:
test mat.
Remarks on result:
other: value as reported in the study

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
2-methycyclohexanone has an acute dermal LD50 of 1.77 mL/Kg. As a result, the substance meets the criteria for classification for Category 1 according to Regulation (EC) No 1272/2008, Annex I section 3.1.