2,6-dimethylpyridine

Endpoint summary

Description of key information

Acute oral toxicity:

The lethal dose (LD50) value for acute oral toxicity test was considered to be 810 mg/kg bw,when rats were treated with test chemical orally.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Remarks:

Read across data

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary literature

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

acute toxic class method

Specific details on test material used for the study:

Substance name: 2-Picoline
CAS no.: 109-06-8
Mol. wt.: 93.13
Smiles: CC1=CC=CC=N1
Physicl state: Liquid
Purity: Not specified

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

Not specified

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

Not specified

Doses:

550 to 1260 mg/kg-bw

No. of animals per sex per dose:

10 males

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Sex:

male

Dose descriptor:

LD50

Effect level:

810 mg/kg bw

Based on:

test mat.

Mortality:

50% Mortality was obseved in rats at dosage concentration of 810mg/kg bw

Clinical signs:

other: not specified

Gross pathology:

not specified

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The lethal dose (LD50) value for acute oral toxicity test was considered to be 810 mg/kg bw,when rats were treated with test chemical orally.

Executive summary:

Acute oral toxicity study was performed in rats using test chemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). 10 male rats of strain Sprague-Dawley were treated at a dose concentration of 550 -1260mg/kg bw. Animals were further observed for clinical signs of toxicity and mortality for 28 days. Mortality in 50% of animal population was observed at dose 810 mg/kg bw. Hence, the LD50 value was considered to be 810mg/kg bw, when rats were treated with test chemical. The test chemical can be considered as "Category 4" according to the CLP.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

810 mg/kg bw

Quality of whole database:

Data is from secondary literature and klimisch 4.

Additional information

Acute oral toxicity:

1. Acute oral toxicity study was performed in rats using testchemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). 10 male rats of strain Sprague-Dawley were treated at a dose concentration of 550 -1260mg/kg bw. Animals were further observed for clinical signs of toxicity and mortality for 28 days.Mortality in 50% of animal population was observed at dose 810 mg/kg bw.Hence, the LD50 value was considered to be 810mg/kg bw, when rats were treated with test chemical. The test chemical can be considered as "Category 4" according to the CLP.

2. Acute oral toxicity study was performed in rats using testchemical 3 -Picoline (CAS no.: 108 -99 -6, E.C. no.: 203 -636 -9). 2 -3 rats per sex per dose of strain Sprague-Dawley were treated at a dose concentration 501, 631, 794 and 1000mg/kg bw. Animals were further observed for clinical signs of toxicity and mortality for 7 days.Mortality in 50% of animal population was observed at dose 710 mg/kg bw.Hence, the LD50 value was considered to be 710mg/kg bw, when rats were treated with test chemical. The test chemical can be considered as "Category 4" according to the CLP.

3. Acute oral toxicity study was performed in rats using testchemical 3 -Picoline (CAS no.: 108 -99 -6, E.C. no.: 203 -636 -9). 3 male rats per dose of Fischer strain were treated at a dose concentration 320, 630, 1300, 2000, 3200 and 5000mg/kg bw. Animals were further observed for clinical signs of toxicity and mortality for 14 days.Mortality in 50% of animal population was observed at dose 630 mg/kg bw.Hence, the LD50 value was considered to be 630mg/kg bw, when rats were treated with test chemical. The test chemical can be considered as "Category 4" according to the CLP.

Justification for classification or non-classification

Based on the above studies for the test chemical, it can be concluded that LD50 value is 810 mg/kg bw for acute oral toxicity, Tus, comparing these values with the criteria of CLP regulation, the given test chemical can be classified as “Category 4” for acute oral toxicity.