Registration Dossier
Registration Dossier
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EC number: 203-321-6 | CAS number: 105-67-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- other: Regulatory report
- Title:
- Toxicological evaluation: 2,4-dimethyl-phenol (CAS No. 105-67-9). No. 137
- Author:
- BG RCI
- Year:
- 2 005
- Bibliographic source:
- Die Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI). https://www.bgrci.de/fileadmin/BGRCI/Downloads/DL_Praevention/Fachwissen/Gefahrstoffe/TOXIKOLOGISCHE_BEWERTUNGEN/Bewertungen/ToxBew137-E.pdf
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test material
- Reference substance name:
- 2,4-xylenol
- EC Number:
- 203-321-6
- EC Name:
- 2,4-xylenol
- Cas Number:
- 105-67-9
- Molecular formula:
- C8H10O
- IUPAC Name:
- 2,4-dimethylphenol
Constituent 1
Results and discussion
Effect levelsopen allclose all
- Key result
- Dose descriptor:
- LD50
- Remarks:
- Rat
- Effect level:
- 3 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 780 - 3 680
- Remarks on result:
- other: apathy, lying on the side, respiratory arrest (no further details)
- Remarks:
- LD50 value from Uschdavini et al., 1974, 1979 studies cited in BG RCI, 2005 report
- Key result
- Dose descriptor:
- LD50
- Remarks:
- Mouse
- Effect level:
- 809 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 724 - 914
- Remarks on result:
- other: apthy, lying on the side, respiratory arrest
- Remarks:
- LD50 value from Uschdavini et al., 1974, 1979 studies cited in BG RCI, 2005 report
- Key result
- Dose descriptor:
- LD50
- Remarks:
- Mouse
- Effect level:
- > 1 000 - <= 1 250 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no deaths; curved position and reeling at 1000 mg/kg bw/day; deaths at 1250 mg/kg bw
- Remarks:
- LD50 value from BASF, 1998b study cited in BG RCI, 2005 report
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Based on literature sources, the LD50 values were reported to be 3500 mg/kg bw in rats and ranged from 809 to 1250 mg/kg bw/day in mice.
- Executive summary:
The BG RCI report on test substance reported three acute toxicity studies conducted in rats and mice. The LD50 values were reported to be 3500 mg/kg bw in rats and ranged from 809 to 1250 mg/kg bw/day in mice (BG RCI, 2005).
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