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EC number: 858-735-5 | CAS number: 2337348-25-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
DPNG does not fulfill the criteria for classification as acute toxic for the oral pathway under CLP
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020-06-02 to 2020-07-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- December 17, 2001
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Japan (Hino Breeding Center)
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: eight weeks
- Weight at study initiation: 192.4 to 204.9g (1st step); 193.1 to 199.0 g (2nd step); individual body weights at the administration of the 2nd step were confirmed to be within +-20% of the mean animal weight at the administration of the 1st step.
- Fasting period before study:
- Housing: three animals per cage or fewer; after group allocation, animals were housed individually until the administration day; hanging stainless steel cages with mesh-floor
- Historical data: yes
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Quarantined/Acclimatized: six days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-25°C
- Humidity (%): 40-70%
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12 hours light
- Fasting period: 17-19 hours before administration; 3-4 hours after administration - Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% (w/v)
- Justification for choice of vehicle: Pretests: Although the test substance did not dissolved and was not suspended to purified water or purified water including 3 v/v% of polyoxyethylene(20) sorbitan monooleate at a concentration of 20 w/v%, the test substance was dissolved to olive oil at a concentration of 20 w/v%. The condition of the formulation such as colour did not change at room temperature four hours after the preparation. Therefore, olive oil was selected as a vehicle.
SUBSTANCE
- Lot/batch no. (if required): 191224
- Purity: 98.8
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg - Doses:
- 1. step: animal 1-3: dose 2000 mg/kg
2. step: animal 4-6: dose 2000 mg/kg - No. of animals per sex per dose:
- 6 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observation: continuously for 10 minutes after the administration, and 30 min., 1 hour, 3 hours and 5 hours after admin. afterwards once per day from day 1-14.; body weights on day 0, 1,7 and 14
- Necropsy of survivors performed: yes - Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality or moribundity occurred at 2000 mg/kg and no abnormalities were observed in any animal in the general clinical observation or necropsy
- Clinical signs:
- other:
- Body weight:
- other body weight observations
- Remarks:
- a decrease was noted in one animal (out of three) of 1st step seven days after administration (-2.7 g). The decrease of the body weight was considered as physiological fluctuation since no abnormalities were observed in the general clinical observation one day after the administration and thereafter, body weights of the other days and gross necropsy, and since a body weight decrease is generally observed in females which are eight weeks old and more. No abnormalities in the 2nd step.
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- or unclassified
- Conclusions:
- DPNG does not fulfill the criteria for CLP classification as acute toxic for the oral pathway.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
DPNG does not fulfill the criteria for classification as acute toxic for the oral pathway under CLP.
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