Registration Dossier
Registration Dossier
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EC number: 266-719-9 | CAS number: 67564-91-4
Endpoint summary
Administrative data
Description of key information
The bioaccumulation potential of the test substance fenpropimorph in Oncorhynchus mykiss and Lepomis macrochirus was assessed in three experimental studies. For fenpropimorph and its metabolites a BCF value in the tested species between 968 and 1145 was determined.
Additional information
In the key study (2003/1009213) The uptake of fenpropimorph in rainbow trout showed to have reached steady-state conditions within 19 days. The bioconcentration factor BCFss based on measured radioactivity in tank water and fish resulted in 1145 for whole fish of the phenyl label and correspondingly in 968 for the morpholine label at steady-state. The depuration of 95% of the residues at the plateau level lasted up to about 56 days. The calculated depuration half-life resulted in 1.4 days for phenyl labelled fenpropimorph and 1.3 days for the morpholine labelled, respectively. The time of 90% elimination was calculated to 4.7 days and 4.2 days, respectively. The kinetic bioconcentration factors BCFk as the ratio of the uptake rate and the depuration rate constants resulted in 1169 (phenyl labelled fenpropimorph) and 1220 (morpholine labelled fenpropimorph) for whole fish. These data are very similar to the BCFss values from direct calculation of the radioactivity measurements of water and fish samples at steady-state.
Metabolisation of fenpropimorph was detected in edible and inedible fish tissue accordingly. Predominant metabolite was the glucuronic acid conjugate BF 421-1-Gluc.A. with up to more than 50% of the radioactive residue.
Two supplementary studies with the bluegill sunfish (Lepomis macrochirus) are available. With phenyl labelled fenpropimorph the observed bioaccumulation factors were 616, 1842 and 1096 for edibles, non-edibles and whole fish, respectively (RCC, 88/10146). The parent compound accounted for the major part of residual radioactivity in the edible parts of fish after 21 end 28 days of exposure. Next to the parent molecule, almost exclusively BF 421-7 and 4-[3-(4-tert-butylphenyl)-2-methyl-1-oxopropyl]-2,6-dimethylmorpholine (BF 421-13) were detected in about 4 to 5 times lower amounts.
Depuration was observed with half-lives of 4.3, 5.3 and 4.8 days for edibles, non-edibles and whole fish, respectively.
Furthermore with morpholine labelled fenpropimorph the observed bioaccumulation factors were 598, 1471 and 942 for edibles, non-edibles and whole fish, respectivly. The parent compound accounted for the major part of residual radioactivity in the edible parts of fish after 21 and 28 days of exposure. Next to the parent molecule, almost exclusively BF 421-7 and 4-[3-(4-tert-butylphenyl)-2-methyl-1-oxopropyl]-2,6-dimethylmorpholine (BF 421-13) were detected in about 4 to 10 times lower amounts. Depuration was observed with half-lives of 8.0. 4.9 and 5.9 days for edibles, non-edibles and whoIe fish, respectively.
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