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EC number: 216-885-3 | CAS number: 1689-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 18 Jun - 15 Jul 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-dibromo-4-cyanophenyl octanoate
- EC Number:
- 216-885-3
- EC Name:
- 2,6-dibromo-4-cyanophenyl octanoate
- Cas Number:
- 1689-99-2
- Molecular formula:
- C15H17Br2NO2
- IUPAC Name:
- 2,6-dibromo-4-cyanophenyl octanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
Iffa Credo, L'Arbresle, France
- Females nulliparous and non-pregnant: not specified
- Age at study initiation:
approximately 6 weeks
- Weight at study initiation:
199 ± 12 g (males) and 165 ± 18 g (females)
- Fasting period before study:
overnight, approximately 18 h before dosing
- Housing:
5 per cage of the same sex in polycarbonate suspended cages containing sawdust bedding
- Diet: A04C pelleted diet (UAR, Villemoisson-sur-Orge, France), ad libitum
- Water: drinking water filtered by a FG Millipore membrane (0.22 micron), ad libitum
- Acclimation period:
at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
21 ± 2
- Humidity (%):
30 - 70
- Air changes (per hr):
12
- Photoperiod (hrs dark / hrs light):
12/12
IN-LIFE DATES: From: 18 Jun To: 15 Jul 1999
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 10 mL/kg bw
- batch no.: 107H1649 (Sigma, Saint-Quentin-Fallavier, France)
DOSAGE PREPARATION
On the day of treatment, the test substance was ground to a fine powder using a mortar and
pestle and the chosen concentrations in the vehicle were prepared. All preparations were made freshly on the morning of administration. - Doses:
- 50 (females), 100 (females) and 200 mg/kg bw (males and females)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Animals were observed frequently during the hours following administration and daily thereafter.
- Frequency of weighing: Animals were weighted before administration of the test substance on Day 1 and then on Days 8 and 15.
- Necropsy of survivors performed: yes, animals were killed by carbon dioxide asphyxiation - Statistics:
- The LD50 value was calculated according to Probit-Analysis (Weber, 1972 and Bliss, 1938). The 70 to 95% confidence interval limits were calculated statistically according to Fieller's method (1944).
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 141 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The toxicity was considered to be comparable in males based on the mortality at 200 mg/kg bw
- Mortality:
- 50 and 100 mg/kg bw: no death occurred (only females were dosed)
200 mg/kg bw: 5/5 females and 3/5 males died on Day 2 following dosing
For details, please refer to attachment 1. - Clinical signs:
- other: 50 and 100 mg/kg bw: no clinical signs were observed (only females were dosed) 200 mg/kg bw: No clinical signs were recorded in females before death. Hypoactivity was observed in all males on Day 1 and persisted on Day 2 in the surviving animals. For det
- Gross pathology:
- No apparent abnormalities were noted at necropsy in animals that survived to termination or died.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The study was performed in accordance with OECD TG 401 under GLP conditions and is considered reliable. Under the conditions chosen, the acute oral LD50 value was determined to be 141 mg/kg bw for female rats. As the male rats were only treated with the highest dose, the exact LD50 value was not determined. However, the toxicity for male rats was considered to be comparable to females based on the mortality at 200 mg/kg bw. According to criteria of the CLP Regulation (EU) No. 1272/2008, classification of the test substance for acute oral toxicity category 3 is warranted.
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