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EC number: 260-300-4 | CAS number: 56634-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Jul - 27 Jul 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity: Fixed Dose Procedure)
- Version / remarks:
- adopted 2017
- Deviations:
- yes
- Remarks:
- No details regarding environmental conditions.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,6-dibromo-4-cyanophenyl heptanoate
- EC Number:
- 260-300-4
- EC Name:
- 2,6-dibromo-4-cyanophenyl heptanoate
- Cas Number:
- 56634-95-8
- Molecular formula:
- C14H15Br2NO2
- IUPAC Name:
- 2,6-dibromo-4-cyanophenyl heptanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ray Nichols Rabbitry, Lumberton. Texas
- Females nulliparous and non-pregnant: yes
- Age at study initiation: young adults
- Weight at study initiation: 2.725 - 3.300 kg (males), 2.400 - 3.425 (females)
- Fasting period before study: no
- Housing: individually in suspended, wire bottom, stainless steel cages
- Diet: Purina Rabbit Chow; ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
IN-LIFE DATES: From: 12 Jul To: 27 Jul 1989
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal area of the trunk
- % coverage: at least 10
- Type of wrap if used: Surgical gauze (10 x 10 cm and two layers thick) was applied to the trunk of the animal and held in place with non-irritating adhesive tape. Then, the trunk was wrapped with a semi-occlusive dressing held in place non-irritating adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing: with room temperature tap water and a clean wet cloth
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 1.32 mL/kg bw
- Constant volume or concentration used: yes
- For solids, paste formed: no but heated to 45 °C in a water bath to liquefy the test substance
- Duration of exposure:
- 24 h
- Doses:
- 2020 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1/2, 3 and 6 h after treatment and at least once daily thereafter
- Frequency of weighing: on Days 0, 7 and 14 or at the time of discovery after death
- Necropsy of survivors performed: yes
- Clinical signs including body weight: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 020 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: except for one female, no mortality occurred.
- Mortality:
- 1 female died on Day 2. The gross necropsy examination conducted on this animal and on each animal which survived through termination of the study revealed no obvious abnormalities.
For details, please refer to Attachment 1. - Clinical signs:
- other: - decreased defecation (1 female, Day 2 - 4, 3 males on Day 2 and 3, 1 male on Day 4) - diarrhea (1 female, Day 13) For details, please refer to Attachment 2.
- Gross pathology:
- At necropsy, the gross pathological examination conducted on the animal that died on Day 2 and on each animal which survived through termination of the study revealed no obvious abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The study was conducted under GLP conditions, according to U.S. EPA guideline No. 81-2, which in principle is similar to the OECD test guideline 402. The resulting LD50 was > 2020 mg/kg bw for both, male and female rabbits. According to criteria of the CLP Regulation (EU) No. 1272/2008, no classification of the test item for acute dermal toxicity is warranted.
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