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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2020-03-02 to 2020-04-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
2.1 mg/L
Conc. based on:
test mat.
Incubation duration:
2 h
Temp.:
20 °C
pH:
4

The maximum concentration measured during the experiment is given as water solubility. This was the case after about 2 hours.


Table 1: Results for the Determination of the water solubility of the test item














































Sample description



Measured pH2 after incubation



Age / h



Concentration detected / µg/L1



Dilution factor



Concentration calculated / µg/L



Replicate 1 Sampling 3



4



2:00



40.009



50



2000.5



Replicate 2 Sampling 3



4



2:00



40.135



50



2006.8



Replicate 3 Sampling 3



4



2:00



44.590



50



2229.5



Replicate 4 Sampling 3



4



2:00



43.463



50



2173.2



1 analysis of a dilution of the saturated solution, rounded value calculated from regression data


2 measured with pH strips


 


The determined concentration from all four samplings at this point in time has been averaged (relative standard deviation: 5.5%) and given as final result.


 

Conclusions:
The water solubility of the test item was determined to be 2.1 mg/L at 20 °C and pH 4.
Executive summary:

The water solubility was determined according to Regulation (EC) No 440/2008, method A.6 and OECD Guideline No. 105, adopted July 27, 1995 using the flask method with GC-MS/MS analysis. Flasks were prepared with an amount of test item and water. After shaking and centrifugation the aqueous phases were measured by means of GC-MS/MS. The whole test was performed as quadruplicate; the samplings were taken repeatedly from of these replicates.


The maximum concentration measured during the experiment is given as water solubility. This was the case after about 2 hours. The water solubility of the test item was determined to be 2.1 mg/L at 20 °C and pH 4.

Description of key information

The water solubility of the test item was determined to be 2.1 mg/L at 20 °C and pH 4 (reference 4.8-1).

Key value for chemical safety assessment

Water solubility:
2.1 mg/L
at the temperature of:
20 °C

Additional information

The water solubility was determined according to Regulation (EC) No 440/2008, method A.6 and OECD Guideline No. 105, adopted July 27, 1995 using the flask method with GC-MS/MS analysis. Flasks were prepared with an amount of test item and water. After shaking and centrifugation the aqueous phases were measured by means of GC-MS/MS. The whole test was performed as quadruplicate; the samplings were taken repeatedly from of these replicates.


The maximum concentration measured during the experiment is given as water solubility. This was the case after about 2 hours. The water solubility of the test item was determined to be 2.1 mg/L at 20 °C and pH 4.