Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 429-130-1 | CAS number: 2820-37-3
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 427 (Skin Absorption: In Vivo Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.7600 (Dermal Penetration)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- no
Test material
- Test material form:
- solid
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Type of coverage:
- semiocclusive
Results and discussion
Percutaneous absorptionopen allclose all
- Time point:
- 8 h
- Parameter:
- percentage
- Absorption:
- 21.63 %
- Time point:
- 24 h
- Parameter:
- percentage
- Absorption:
- 33.07 %
- Time point:
- 120 h
- Parameter:
- percentage
- Absorption:
- 26.39 %
- Time point:
- 8 h
- Parameter:
- percentage
- Absorption:
- 22.61 %
- Time point:
- 120 h
- Parameter:
- percentage
- Absorption:
- 27.54 %
- Time point:
- 8 h
- Parameter:
- percentage
- Absorption:
- 15.41 %
- Time point:
- 120 h
- Parameter:
- percentage
- Absorption:
- 20.82 %
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
