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EC number: 236-283-4 | CAS number: 13280-60-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Flash point
Administrative data
- Endpoint:
- flash point of flammable liquids
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the flash point is only relevant to liquids and low melting point solids
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 August - 11 September 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- EC No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- Batch No.: 10044431
Storage Conditions: Room temperature (approx. 15 to 25 °C) - Key result
- Melting / freezing pt.:
- 249.5 °C
- Atm. press.:
- 1 004.3 hPa
- Decomposition:
- yes
- Decomp. temp.:
- ca. 250 °C
- Conclusions:
- The test item 5-Amino-2-nitrobenzoic acid (CAS no. 13280-60-9) has a melting point of 249.5 °C at atmospheric pressure (1004.3 hPa) accompanied by its decomposition starting at a temperature of approx. 250 °C as determined by differential scanning calorimetry and capillary method according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
- Executive summary:
The test item 5-Amino-2-nitrobenzoic acid (CAS no. 13280-60-9) has a melting point of 249.5 °C at atmospheric pressure (1004.3 hPa) accompanied by its decomposition starting at a temperature of approx. 250 °C as determined by differential scanning calorimetry and capillary method according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
During the heating phase a distinct endothermic effect was observed in the temperature range of 240 – 250 °C, which can be assigned to the melting of the test item. The endothermic effect was directly followed by an exothermic effect starting at a temperature of approx. 250 °C with an average decomposition energy of -750 J/g.
No. | Sample weight (mg) | Onset of effect (°C) | Range of effect (°C) | Weight loss (mg) | Atmospheric pressure (hPa) |
PN18264 |
9.44 | 249.65 | 240 - 250 (endo) 250 - 320 (exo) |
5.04 | 1004.3 |
PN18265 | 10.58 | 249.26 | 240 - 250 (endo) 250 - 320 (exo) |
4.69 |
1004.3 |
As the onset temperatures in both tests deviate by less than 0.5 K from their mean value of 249.46 °C, this temperature can be used as melting point. The test item has a melting point of 249.5 °C accompanied by its decomposition.
Optical verification using the capillary method
To verify the results of the DSC measurement, an additional measurement in a melting capillary was performed in the temperature range of 200 °C to 260 °C with a heating rate of 10 K/min. Starting at a temperature of 240 °C change in colour to a darker tone could be observed. At a temperature of 250 °C the test item was completely molten and turned black. The test was terminated at a maximum temperature of 260 °C. After the measurement a black residue remained in the capillary.
According to the observations during the test in the capillary method, the effects in the DSC measurements with open crucibles can be assigned to the melting of the test item accompanied by its decomposition in the temperature range of 240 °C to 250 °C.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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