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EC number: 701-399-0
CAS number: -
The reaction product of copper sulfate and triethylenetetramine is
formed by mixing triethylenetetramine
(TETA) and copper sulfate (CuSO4).
TETA is known as a skin sensitiser (ECHA dissemination database), which
was confirmed by QSAR predictions (TOXTREE).
CuSO4 is not known as a skin sensitiser, as indicated by an extensive
review in the context of the voluntary risk assessment of copper.
As a worst-case approach, the reaction product of copper sulfate and
triethylenetetramine is regarded as a skin sensitiser based on the known
skin sensitisation properties of TETA.
Copper sulphate pentahydrate failed to induce skin sensitisation
in a GPMT (Mercier 1994 a– unpublished). Concentrations of
test substance selected for induction and challenge were based on
results of a sighting study. Induction involved intradermal injection of
test substance (0.1% in water) on day 0, a concentration which produced
weak to moderate irritation in the sighting study. This was followed by
topical application of test substance (10% in water) on day 7 for 48
hours. Sodium lauryl sulphate (10%) was also applied at topical
induction, prior to the test substance, as the test substance alone at a
concentration of 10% failed to provoke signs of irritation in the
sighting study. The skin response at topical induction in the main study
was not reported. After an 11-day treatment-free period, animals were
challenged by topical application of the test substance (10% in water)
under an occlusive dressing for 24 hours. Skin response was assessed in
animals (20 treated and 9 controls) at 24 and 48 hours after
challenge. Slight erythema was observed in one treated animals at 24
hours, but not at 48 hours. No skin reactions occurred other treated
animals or in controls at either time-point. In conclusion, copper
sulphate pentahydrate produced a 0% sensitisation rate under the
conditions of this test and is therefore considered to have no skin
sensitising potential in guinea pigs.
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