Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-623-0 | CAS number: 9001-66-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance does not dissolve in water or in octanol
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
A study on CDX-616 was performed to determine the partition coefficient of the test substance, Monoamine Oxidase enzyme, according to OECD Method 107. The study was conducted to comply with the requirements of European Council Directive for 91/414/EEC (Annex II) as amended by European Commission Directive 94/37/EC and amended by Commission Regulation (EU) No. 544/2011 Implementing Regulation (EC) Nov 1107/2009 of the European Parliament and of the Council as regards the data requirements for active substances. There was no solubility in the octanol phase at 23 °C and therefore no reportable value is available.
A log Kow of -3 at 23 °C (HERA value reported for amylase, lipase, and cellulase:) will be used for the purposes of a Chemical Safety Assessment.
Reference:
HERA Human and environmental risk assessment on ingredients of household cleaning products - alpha-amylases, cellulases and lipases. 2005 - Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Description of key information
The test substance does not dissolve in the octanol phase at 23 °C and therefore it is not technically feasible to determine the n-octanol/water partition coefficient. A conservative Log Kow of -3 will be used for the purposes of a Chemical Safety Assessment.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3
- at the temperature of:
- 23 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
