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Diss Factsheets
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EC number: 482-150-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 24 October 2007 and 14 November 2007.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Magenta T-43
- IUPAC Name:
- Magenta T-43
- Test material form:
- solid: particulate/powder
- Details on test material:
- Sponsor's identification: MAGENTA T-43
Description: dark red solid
Storage conditions: room temperature, in the dark
Lot number: H186-5
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Analysis of sample solutions:
Aliquots of the sample solutions were taken from the flasks at various times and the pH of each solution recorded. The concentration of the sample solution was determined by high performance liquid chromatography (HPLC).
Samples:
Duplicate samples (A and B) were analysed neat. - Buffers:
- The specification of buffered solutions were as follows:
Potassium hydrogen phthalate; pH 4; conc. 0.005 mol dm-3
Disodium hydrogen orthophophate (anhydrous); pH 7; conc. 0.003 mol dm-3
Potassium dihydrogen orthophosphate; pH 7; conc. 0.002 mol dm-3
Sodium chloride; pH 7; conc. 0.002 mol dm-3
Disodium tetraborate; pH 9; conc. 0.001 mol dm-3
Sodium chloride; pH 9; conc. 0.002 mol dm-3
The buffer solutions were filtered through a 0.2 µm membrane filter to ensure they were sterile before commencement of the test. Also these solutions were subjected to ultrasonication and degassing with nitrogen to minimise dissolved oxygen content. - Estimation method (if used):
- Not applicable
- Details on test conditions:
- Preparation of samples:
Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 0.2 g/l in the three buffer solutions.
The solutions were shielded from light whilst maintained at the test temperature.
Preliminary test:
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5°C for a period of 5 days.
Duration of testopen allclose all
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50
- Number of replicates:
- Samples:
Duplicate samples (A and B)
Standards:
Duplicate standard solutions - Positive controls:
- no
- Negative controls:
- no
Results and discussion
- Transformation products:
- not specified
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Details on results:
- Results:
For pH 4, 7 and 9 the results show that less than 10% hydrolysis was achieved after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
Any other information on results incl. tables
Validation:
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 500 mg/l. This was satisfactory with a correlation coefficient of 1.00 being obtained.
Preliminary Test Results
Solution |
Mean Peak Area |
Standard 202 mg/l Standard 200 mg/l Initial Sample A, pH4 Initial Sample B, pH 4 |
2032 2001 2049 2068 |
Standard 202 mg/l Standard 200 mg/l Initial Sample A, pH 7 Initial Sample B, pH 7 |
2036 2014 2064 2058 |
Standard 202 mg/l Standard 200 mg/l Initial Sample A, pH 9 Initial Sample B, pH 9 |
2027 2017 2037 2037 |
Standard 201 mg/l Standard 203 mg/l 24 Hour Sample A, pH 4 24 Hour Sample B, pH 4 |
1656 1679 1693 1703 |
Standard 201 mg/l Standard 203 mg/l 24 Hour Sample A, pH 7 24 Hour Sample B, pH 7 |
1664 1680 1702 1716 |
Standard 201 mg/l Standard 203 mg/l 24 Hour Sample A, pH 9 24 Hour Sample B, pH 9 |
1659 1689 1691 1688 |
Standard 202 mg/l Standard 202 mg/l 48 Hour Sample A, pH 4 48 Hour Sample B, pH 4 |
1692 1694 1709 1695 |
Standard 202 mg/l Standard 202 mg/l 48 Hour Sample A, pH 7 48 Hour Sample B, pH 7 |
1700 1685 1706 1689 |
Standard 202 mg/l Standard 202 mg/l 48 Hour Sample A, pH 9 48 Hour Sample B, pH 9 |
1699 1685 1686 1686 |
Standard 202 mg/l Standard 202 mg/l 120 Hour Sample A, pH 4 120 Hour Sample B, pH 4 |
1669 1679 1711 1707 |
Standard 202 mg/l Standard 202 mg/l 120 Hour Sample A, pH 7 120 Hour Sample B, pH 7 |
1684 1692 1718 1721 |
Standard 202 mg/l Standard 202 mg/l 120 Hour Sample A, pH 9 120 Hour Sample B, pH 9 |
1670 1691 1686 1682 |
Main Test Results:
pH 4 at 50.0 ± 0.5°C
Time (Hours) |
||||
|
0 |
24 |
48 |
120 |
Concentration (g/l) |
0.206 |
0.206 |
0.203 |
0.206 |
% of initial |
100 |
100 |
98.9 |
100 |
Result: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
pH 7 at 50.0 ± 0.5°C
Time (Hours) |
||||
|
0 |
24 |
48 |
120 |
Concentration (g/l) |
0.205 |
0.206 |
0.203 |
0.206 |
% of initial |
100 |
100 |
98.9 |
100 |
Result: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
pH 9 at 50.0 ± 0.5°C
Time (Hours) |
||||
|
0 |
24 |
48 |
120 |
Concentration (g/l) |
0.203 |
0.204 |
0.201 |
0.202 |
% of initial |
100 |
100 |
99.3 |
99.6 |
Result: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated half-life at 25 °C of the test material at pH 4, pH 7 and pH 9 has been shown to be >1 year.
- Executive summary:
The estimated half-life of the test substance Magenta T-43 was shown to be >1 year at pH 4, 7 and 9 at 25 °C according to method C7 of Commission Directive 92/69/EEC using the Hydrolysis as a Function of pH test method.
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