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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable screening method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
Inhalation hazard test as in the annex of the guideline
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium sarcosinate
EC Number:
224-338-5
EC Name:
Sodium sarcosinate
Cas Number:
4316-73-8
Molecular formula:
C3H6NNaO2
IUPAC Name:
sodium (methylamino)acetate

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: water
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
nominal concentration: 3.41 mg/l
No. of animals per sex per dose:
6 (tests were performed in 2 trials with 3 animals/sex/trial)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 8 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
3.41 mg/L air (nominal)
Exp. duration:
8 h
Remarks on result:
other: No mortalities observed
Mortality:
No mortalities observed
Clinical signs:
other: No abnormalities observed
Body weight:
not determined
Gross pathology:
One animal suffered from bronchitis

Applicant's summary and conclusion