Registration Dossier

Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23.-24.10.2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
agglomerate
Type of distribution:
volumetric distribution
Key result
Percentile:
D10
Mean:
ca. 1.3 µm
Remarks on result:
other: St. dev. not determined
Key result
Percentile:
D50
Mean:
ca. 4.9 µm
Remarks on result:
other: st. dev. not determined.
Key result
Percentile:
D90
Mean:
ca. 16.4 µm
Remarks on result:
other: st. dev. not determined.

The test item was a fine white powder with chunks. Under the microscope needle-shaped crystalline particles were observed. The fluffy needle-shaped particles of the test item tended to agglomerate. The test item was sieved with a mesh size of 1000 μm. 28.5 % (w/w) of the test item passed the sieveand only this fraction was measured with laser diffraction. The particles were introduced to the analyser beam by the dry powder feeder by direct spraying through the measurement area. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air. After passing the analyser beam the sample was collected in a vacuum cleaner. After adjusting the laser, measuring the background and adjusting the correct particle concentration (obscuration) the measurement was started. The control software automatically performed three measurements. The average of these three measurements was given as result. Two test series of three measurements each were performed. The measurement time was 8 s. Median values were calculated from unrounded values.

 

The median particle size L50(D (v, 0.5): 50 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: L50= 4.8 μm

2nd test series: L50= 5.1 μm

The average of the median particle size L50was: L50= 4.9 μm

 

The particle size L10 (D (v, 0.1 ): 10 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: L10= 1.3 μm

2nd test series: L10= 1.4 μm

The average of the particle size L10was: L10= 1.3 μm

 

The particle size L90(D (v, 0.9): 90 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1sttest series: L90= 14.9 μm

2nd test series: L90= 17.9 μm

The average of the particle size L90was: L90= 16.4 μm

 

The maximum was observed at approximately 5 μm. Additionally, a shoulder was observed at approximately 0.5 μm. In the second measurement an additional maximum was observed at approximately 250 μm.

Conclusions:
The median particle size L50 of the test item deduced from the particle size distributions was 4.9 µm.
Executive summary:

The median particle size L50 of the test item deduced from the particle size distributions was 4.9 µm.

Description of key information

The median particle size L50 of the test item deduced from the particle size distributions was 4.9 µm.

Additional information

Categories Display