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EC number: 456-990-3 | CAS number: 244761-29-3 LITHIUM-BIS(OXALATO)BORATE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-08-17 to 2010-02-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Version / remarks:
- October 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- April 29, 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- December, 2002
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- Lithium bis(oxalato)borate
- EC Number:
- 456-990-3
- EC Name:
- Lithium bis(oxalato)borate
- Cas Number:
- 244761-29-3
- Molecular formula:
- C4BLiO8 (Hill Empirical Formula) C4BO8.Li (CAS Empirical Formula)
- IUPAC Name:
- boron(3+) lithium(1+) dioxalate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (Europe) Laboratories Inc. TOXI COOP Ltd. 1103 Budapest, Cserkesz u. 90
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 203-229 g
- Fasting period before study: food but not water was withheld for 24h before treatment
- Housing: 1 animal/cage (Type II. polypropylene/polycarbonate)
- Diet (e.g. ad libitum): ssniff SM R/M-Z+H, ad libitum
- Water (e.g. ad libitum): tap water from municipal supply, ad libitum
- Acclimation period: at least 13 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.4-24.7
- Humidity (%): 38-67%
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 17.5, 55, 200 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw
- Lot/batch no. (if required): 058K0070 - Doses:
- 175, 550, 2000 mg/kg bw
- No. of animals per sex per dose:
- treatment group 1 (175 mg/kg bw): 2 females
treatment group 2 (550 mg/kg bw): 4 females
treatment group 3 (2000 mg/kg bw): 1 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were done daily
- Necropsy of survivors performed: yes
- clinical signs: were observed 30 min, 1, 2, 3, 4 and 6 hours after treatment and once each day for 14 days thereafter
- body weight: were recorded on days -1, 0 (day of experiment), and on days 7 and 14
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 550 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 88.94 - 2 430
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 175 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Treatment group 1: 175 mg/kg bw
No mortality occurred in this group.
Treatment group 2: 550 mg/kg bw
Treatment with lithium bis(oxalato)borate (LiBOB) at a dose level of 550 mg/kg bw caused mortality in case of 2 animals (2/3).
One female died died shortly after treatment due to a dosing accident (misgavage) and/or gastro-esophageal reflux (not test item related).
Treatment group 3: 2000 mg/kg bw
Treatment with lithium bis(oxalato)borate (LiBOB) at a dose level of 2000 mg/kg bw caused mortality in this dose group. - Clinical signs:
- other: In Treatment group 1 LiBOB caused decreased activity in one out of two rats. In Treatment group 2 a decreased activity in one out of 4 rats was observed.
- Gross pathology:
- Treatment group 1: 175 mg/kg bw
Treatment with lithium bis(oxalato)borate (LiBOB) at a dose level of 175 mg/kg bw caused dilatation, (pelvis, right) and white cloudy fluid in one rat’s kidneys in this dose group.
Treatment group 2: 550 mg/kg bw
Treatment with lithium bis(oxalato)borate (LiBOB) at a dose level of 550 mg/kg bw caused diffuse dark red discoloration of the lungs and liver, dark, punctuate red discoloration of the thymus (bilateral) and dark, red, diffuse discoloration and mucosa in ileum in this dose group.
Treatment group 3: 2000 mg/kg bw
Treatment with lithium bis(oxalato)borate (LiBOB) at a dose level of 2000 mg/kg bw caused diffuse dark red discoloration of the liver and dark, red, diffuse discoloration and mucosa in ileum, duodenum and jejunum in this dose group.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Lithium bis(oxalato)borate (LiBOB) was ranked into Category 4 of Globally Harmonized Classification System as the estimated LD50 is between 300 and 2000 mg/kg bw.
- Executive summary:
An acute oral toxicity study (up-and-down procedure) was performed with lithium bis(oxalato)borate (LiBOB) according to OECD Guideline 425. 7 young female CRL:(WI) BR Wistar rats were treated with the test item by oral gavage at dose levels of 175, 550 and 2000 mg/kg bw in corn oil. The concentrations of the formulations in corn oil were 200, 55 and 17.5 mg/mL with a constant treatment volume of 10 mL/kg bw.
Lithium bis(oxalato)borate (LiBOB) caused 100% mortality at 2000 mg/kg bw (1/1 animal) and 67% (2/3 animals) mortality at 550 mg/kg bw. There was no mortality at 175 mg/kg bw.
Treatment with lithium bis(oxalato)borate (LiBOB) caused mortality at a dose level of 2000 mg/kg bw, decreased activity (1/3) and mortality (2/3) at 550 mg/kg bw and decreased activity (1/2) at 175 mg/kg bw.
The body weight gain of the animals was considered to be normal with no indication of test item related effect.
The macroscopic examination revealed some minor alterations including diffuse dark red discoloration of the lungs (1/6) and liver (3/6), dark, punctuate red discoloration of the thymus (bilateral) (1/6), dark, red, discoloration, diffuse, mucosa in ileum (2/6), duodenum, jejunum (1/6). Dilatation, (pelvis, right) and white cloudy fluid was found in one rat’s kidneys.
The study was marked reliable without restrictions and LD50 and LD0 values of 550 and 175 mg/kg bw respectively were derived. (LAB, 2010)
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