Registration Dossier
Registration Dossier
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EC number: 433-730-7 | CAS number: 23926-51-4 L-THREONINETHYLESTER
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000.04.04-2000.09.21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study performed in accordance with GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Principles of method if other than guideline:
- NA
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 20 °C
- Remarks on result:
- other: NA
- Details on results:
- The retention time of L-TEE : 2.484 min.
The retention time of Formamide (the void volume marker): 2.437 min.
The retention time of Butanone (the calibration compound): 3.405 min. - Conclusions:
- The partition coefficient of L-TEE was determined in accordance with EU Method A.8 and OECD Guideline 117. The log Pow of L-TEE was determined to be below 0.3
- Executive summary:
The partition coefficient of L-TEE was determined in accordance with EU Method A.8 and OECD Guideline 117.
The octanol-water partition coefficient of L-TEE was evaluated using the HPLC simulation technique with methanol-water, 55:45 as eluent. L-TEE eluted as a single component with a retention time effectively equivalent to that of the void volume marker formamide, and therefore the partition coefficient, whilst being below a log Pow value of 0.3, could not be more fully numerically evaluated.
Reference
NA
Description of key information
The log Pow of L-TEE was determined to be below 0.3
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.3
- at the temperature of:
- 35 °C
Additional information
The partition coefficient of L-TEE was determined in accordance with EU Method A.8 and OECD Guideline 117.
The octanol-water partition coefficient of L-TEE was evaluated using the HPLC simulation technique with methanol-water, 55:45 as eluent. L-TEE eluted as a single component with a retention time effectively equivalent to that of the void volume marker formamide. Therefore, the partition coefficient could not be more numerically evaluated, but is below 0.3.
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