Ethyl L-threoninate

Oxidising properties

Link to relevant study record(s)

Reference

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2007.08.31 to 2007.11.29

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study performed in accordance with recognized test guidance.

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.17 (Oxidising Properties (Solids))

GLP compliance:

yes

Contact with:

powdered cellulose

Sample tested:

test mixture (not specified)

Remarks:

migrated information

Parameter:

maximum burning rate

Result:

2.33 other: mm/s (migrated information)

Remarks on result:

other: 50% test substance

Sample tested:

reference mixture (not specified)

Remarks:

migrated information

Parameter:

maximum burning rate

Result:

0.68 other: mm/s (migrated information)

Remarks on result:

other: 60% reference substance

No vigorus reactions during the tests.

A false positive test was made, where cellulose was substitued by kieselguhr in the train test. Kieselguhr cannot be oxidized and therefore if the burning propagates along trains containing kieselguhr mixture with the test substance, then this is due to entirely burning of the test substance and not to potential oxidative properties. This constitutes a false positive test. This was conducted using mixtures containing between 10 and 90% test substance.

The mixtures of 10, 20, 30 and 40% test substance failed to ignite. The 50% test substance mixture burned with a sooty flame, but only covered a distance of 25 mm. The mixtures of 60, 70 and 80% test substance burned with a sooty flame but not through the whole sample. The burning rate were 4.00, 5.41 and 2.17 mm/sec respectively. The 90% test substance mixture appeared to melt. There were no vigorous reaction during the tests.

Interpretation of results:

GHS criteria not met

Conclusions:

The oxidising properties of L-Threonine Ethyl Ester (L-TEE) were evaluated in accordance with EU Method A.17 (Oxidising Properties for Solids). L-TEE was found to be not oxidising.

Executive summary:

The oxidising properties of L-Threonine Ethyl Ester were evaluated in accordance with EU Method A.17 (Oxidising Properties for Solids).

The burning rates of the test substance mixtures with cellulose were higher than that of the test substance. This suggested that L-TEE may be oxidising and further evaluation was required.

The burning rates in the presence of kieselguhr were higher than those of the equivalent mixtures containing cellulose. This indicates that L-TEE cannot be oxidising because an oxidising material would burn slower in the presence of kieselguhr.

The burning characteristics recorded throughout the test (no vigorous reactions, sooty flame or clean blue flame) are not indicative of oxidation.

The calculated oxygen balance (-168.5%) indicates that L-TEE is within the region where a potential for oxidising properties exists, but there are no potential auxoploses/plosophores present in the chemical structure.

Overall, L-TEE is not considered to be oxidising.

Description of key information

The test results indicated that the test material (L-TEE)  is not oxidising. 

Key value for chemical safety assessment

Oxidising properties:

no

Additional information

The oxidising properties of L-TEE were evaluated in accordance with EU Method A.17 (Oxidising Properties for Solids).

The burning rates of the test substance mixtures with cellulose were higher than that of the reference substance. This suggested that L-TEE may be oxidising and further evaluation was required.

The burning rates in the presence of kieselguhr were higher than those of the equivalent mixtures containing cellulose. This indicates that L-TEE cannot be oxidising because an oxidising material would burn slower in the presence of kieselguhr.

The burning characteristics recorded throughout the test (no vigorous reactions, sooty flame or clean blue flame) are not indicative of oxidation.

The calculated oxygen balance (-168.5%) indicates that L-TEE is within the region where a potential for oxidising properties exists, but there are no potential auxoploses/plosophores present in the chemical structure.

Overall, L-TEE is not considered to be oxidising.

Justification for classification or non-classification

Based on these results, L-TEE is not expected to have hazardous properties and is not classified according to GHS and DSD-DPD.