Registration Dossier
Registration Dossier
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EC number: 201-740-9 | CAS number: 87-33-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: information from secondary source
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- A reliable secondary source, summaring ISDN pharmaco-toxicological properties, was used. However, the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used. The used secondary source has been updated on January, 2011; therefore it covers the most updated literature on the substance.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 2 011
- Bibliographic source:
- Chem ID plus lite
- Reference Type:
- secondary source
- Title:
- No information
- Year:
- 2 011
- Bibliographic source:
- RTECS - Registry of Toxic Effects of Chemical Substances
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No detailed information is available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isosorbide dinitrate
- EC Number:
- 201-740-9
- EC Name:
- Isosorbide dinitrate
- Cas Number:
- 87-33-2
- Molecular formula:
- C6H8N2O8
- IUPAC Name:
- isosorbide dinitrate
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 747 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance should be classified for oral acute toxicity as Xn R22 and Acute Tox 4 H302
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