(R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2013

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

(R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride

EC Number:

415-110-8

EC Name:

(R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride

Cas Number:

54417-53-7

Molecular formula:

C20H25NO4.HCl

IUPAC Name:

(1R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Test material form:

solid: crystalline

Test solutions

Vehicle:

no

Details on test solutions:

Identity and concentration of auxiliary solvent for dispersal: Direct dispersion in water

Test organisms

Test organisms (species):

Daphnia magna

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

105 mg/L

Nominal / measured:

meas. (not specified)

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

48 mg/L

Nominal / measured:

meas. (not specified)

Effect concentrations 3

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

22 mg/L

Nominal / measured:

meas. (not specified)

Details on results:

Measured concentrations were 98-106% of the nominal
Elendt M7 medium used
Test results are based on mean measured concentrations