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EC number: 209-567-0 | CAS number: 585-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 11 April 2018 to 15 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- version 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- version 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Identification : MALTITOL
CAS No. : 585-88-6
EC No. : 209-567-0
Batch ELEL7
Appearance White powder - Analytical method:
- other: Ionic chromatography using amperometric detection
- Key result
- Type:
- log Pow
- Partition coefficient:
- -3.87
- Temp.:
- 24 °C
- pH:
- 6.6 - 6.8
- Details on results:
- Three assays, each in duplicate, were performed using different ratio of solvent volumes (2:1; 1:1 and 1:2).
The mean log Pow = -3.87 ; SD = 0.03 ; RSD = 0.76%.
The quality criteria are fulfilled. - Conclusions:
- The log Pow of Maltitol was determined as -3.87 ± 0.03 using the shake flask method.
- Executive summary:
The coefficient of partition of Maltitol was determined according to the EU method A.8 and OECD 107, and in compliance with GLP.
Since the maltitol is highly hydrophilic, the shake flask method was used to measure its partition between the aqueous phase and the n-octanol phase.
Each phase was first saturated with the other solvent. The concentration of the starting water test item solution was equal to 3.00 g/L. Three assays, each in duplicate, were performed using different ratio of solvent volumes (2:1; 1:1 and 1:2). Each mixture was shaken using a magnetically stirrer for about 15 minutes at 24 °C ± 1 °C. The temperature during the partition phase was equal to 24 °C ± 1 °C.
Then two phases were separated and the maltitol concentration was analysed in each solvent using the ionic chromatography with amperometric detection. The analysis method was demonstrated to satisfy the SANCO/3030/99 rev.4 regarding the specificity, linearity, accuracy and precision (Report 18 -918023 -004).
The pH of the aqueous phase solutions after the partition was between 6.68 and 6.80 at 22.0 °C.
The mean log Kow is equal to -3.87 ± 0.03 and the relative standard deviation = 0.76%.
The log Kow study is classified as acceptable, and satisfies the guideline requirements of the EU method A.8 and OECD 107.
Reference
Calibration curve for the aqueous phases
A = 3.54 x C + 2.36 and R=0.9987
Calibration curve for the n-octanol phases
A = 6.13 x C + 2.97 and R=0.9997
Partition coefficient results
Identification |
Peak Area Atest |
Mean peak Area Atest |
Conc. after Dilution (mg/L) Cd |
Dolution Factor Df |
Conc. before Dilution (mg/L) C |
Coctanol/ Cwater |
Log Pow |
18-078 A8 A |
6.5663 |
6.5670 |
1.19 |
2500 |
2974 |
0.000147 |
-3.833 |
6.5676 |
|||||||
18-078 A8 A |
8.4371 |
8.3257 |
0.87 |
0.5 |
0.44 |
||
8.2143 |
|||||||
18-078 A8 B |
6.5071 |
6.5023 |
1.17 |
2500 |
2929 |
0.000136 |
-3.865 |
6.4975 |
|||||||
18-078 A8 B |
7.8614 |
7.8678 |
0.80 |
0.5 |
0.40 |
||
7.8741 |
|||||||
18-078 A8 C |
6.5367 |
6.5351 |
1.18 |
2500 |
2952 |
0.000138 |
-3.860 |
6.5334 |
|||||||
18-078 A8 C |
7.9807 |
7.9620 |
0.81 |
0.5 |
0.41 |
||
7.9432 |
|||||||
18-078 A8 D |
6.5591 |
6.5542 |
1.19 |
2500 |
2965 |
0.000135 |
-3.871 |
6.5493 |
|||||||
18-078 A8 D |
7.8795 |
7.8635 |
0.80 |
0.5 |
0.40 |
||
7.8474 |
|||||||
18-078 A8 E Phaqdil |
6.5740 |
6.5732 |
1.19 |
2500 |
2979 |
0.000119 |
-3.923 |
6.5723 |
|||||||
18-078 A8 E PhocdilA |
7.2880 |
7.3352 |
0.71 |
0.5 |
0.36 |
||
7.3823 |
|||||||
18-078 A8 F |
6.5734 |
6.5765 |
1.19 |
2500 |
2981 |
0.000131 |
-3.882 |
6.5795 |
|||||||
18-078 A8 F |
7.7640 |
7.7653 |
0.78 |
0.5 |
0.39 |
||
7.7666 |
MeanLogPow |
-3.87 |
SD |
0.03 |
RSD |
0.76% |
Description of key information
The log Pow of Maltitol was determined as -3.87 ± 0.03 using the shake flask method.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -3.87
- at the temperature of:
- 24 °C
Additional information
The coefficient of partition of Maltitol was determined according to the EU method A.8 and OECD 107, and in compliance with GLP.
Since the maltitol is highly hydrophilic, the shake flask method was used to measure its partition between the aqueous phase and the n-octanol phase.
Each phase was first saturated with the other solvent. The concentration of the starting water test item solution was equal to 3.00 g/L. Three assays, each in duplicate, were performed using different ratio of solvent volumes (2:1; 1:1 and 1:2). Each mixture was shaken using a magnetically stirrer for about 15 minutes at 24 °C ± 1 °C. Then the two phases were separated and the maltitol concentration was analysed in each solvent using the ionic chromatography with amperometric detection. The analysis method was demonstrated to satisfy the SANCO/3030/99 rev.4 regarding the specificity, linearity, accuracy and precision (Report 18 -918023 -004).
The pH of the aqueous phase solutions after the partition was between 6.68 and 6.80 at 22.0 °C.
The mean log Kow is equal to -3.87 ± 0.03 and the relative standard deviation = 0.76%.
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