Registration Dossier
Registration Dossier
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EC number: 250-125-1 | CAS number: 30315-46-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs
- Principles of method if other than guideline:
- ACD/Percepta (Advanced Chemistry Development, Inc., Pharma Algorithms, Inc.) (release 2018.2.5)
- GLP compliance:
- no
- Test type:
- other: QSAR
Test material
- Reference substance name:
- (S)-3-(tert-butylamino)propane-1,2-diol
- EC Number:
- 250-125-1
- EC Name:
- (S)-3-(tert-butylamino)propane-1,2-diol
- Cas Number:
- 30315-46-9
- Molecular formula:
- C7H17NO2
- IUPAC Name:
- 3-(tert-butylamino)propane-1,2-diol
- Test material form:
- solid: particulate/powder
1
- Specific details on test material used for the study:
- Smile: CC(C)(C)NC[C@H](O)CO
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 900 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Acute oral LD50 in rat equal to 2900 mg/kg (non toxic, no classification is required).
The target compound 1-tert-Butylamino-2,3-propanediol, (S)- is included in the model applicability domain since the RI is greater than 0.3 (RI equal to 0.31). Borderline reliable.
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