Registration Dossier
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EC number: 452-280-2 | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 March to 12 March 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- conducted under GLP conditions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- dynamic method
- Specific details on test material used for the study:
- Description: colourless to pale yellow liquid
Batch: TQT0300497
Purity: 90.9 %
Expiration date: November 28, 2004 - Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.9 Pa
- Remarks on result:
- other: 0.9 +/- 0.04 Pa
- Conclusions:
- Using the Static Technique, the vapour pressure of Karmalone at 20°C is:
vapour pressure (20°C) = 0.90 +/- 0.04 Pa = (6.7 +/- 0.3)x10^-3 mm Hg - Executive summary:
The determination of the vapour pressure of Karmalone was performed in accordance with the following guidelines:
- European Economic Community /EEC), EEC directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.4 "Vapour pressure", EEC Publication No. L383, December 1992
- Organisation for Economic Co-operation and Development (OECD), OECD guidelines for Testing chemicals, Guideline No. 104: "Vapour pressure curve", July 27, 1995
Using the Static Technique, the vapour pressure of Karmalone at 20°C is:
vapour pressure (20°C) = 0.90 +/- 0.04 Pa = (6.7 +/- 0.3)x10^-3 mm Hg
Reference
According to the OECD guideline, the recommended range for the Static method is: 10 up to 10^5 Pa. However, when using a capacitance manometer, the Static method can be used below 10^-1 Pa (according to guideline's paragrapg "Apparatus"). This study was performed using a capacitance manometer with a measurement range of 6x10^-3 Pa - 2x10^5 Pa. The vapour pressures measured for Karmalone at the three test temperatures were all between 1.9 and 46 Pa.
All sensors, thermometers and pressure sensor heads were calibrated over the ranges used in the experiments. Pressure sensor heads were calibrated from high vacuum (<< 10^-5 Pa) to be read as "0" value up to 1 Pa. The thermometers were calibrated in the measurement range used for testing.
Description of key information
The determination of the vapour pressure of Karmalone was performed in accordance with the following guidelines:
- European Economic Community /EEC), EEC directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.4 "Vapour pressure", EEC Publication No. L383, December 1992
- Organisation for Economic Co-operation and Development (OECD), OECD guidelines for Testing chemicals, Guideline No. 104: "Vapour pressure curve", July 27, 1995
Using the Static Technique, the vapour pressure of Karmalone at 20°C is:
vapour pressure (20°C) = 0.90 +/- 0.04 Pa = (6.7 +/- 0.3)x10^-3 mm Hg
Key value for chemical safety assessment
- Vapour pressure:
- 0.9 Pa
- at the temperature of:
- 20 °C
Additional information
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