Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 941-731-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because a study on acute toxicity by the inhalation route is available
- Justification for type of information:
- Lutetium-yttrium oxyorthosilicate, cerium doped is an inorganic material that is manufactured from the underlying metal oxides by the Czochralski technique. As starting materials metal oxides of the following metals are used: Lu, Y, Si, Ce. Referring to the results of the water solubility test (see IUCLID endpoint 4.8 of the technical dossier) only (very) low metal concentrations have been detected during and after the 36-day solubilisation phase. In order to prove that even these low concentrations pose no hazards after a short-term exposure via oral route (e.g. after incidental swallowing), classifications of the underlying metals/metal oxides – as indicated in the registration dossiers and C&L notifications - are taken into account [1 - 7]. The cited classifications underline the absence of acute toxicological properties for the metals/metal oxides in lutetium-yttrium oxyorthosilicate, cerium doped. Considering furthermore the appearance of lutetium-yttrium oxyorthosilicate, cerium doped - in particular the sizes of the grown crystal and the cut smaller crystals - it can reasonably be stated that oral uptake is not the most probable route of exposure. During handling and use of lutetium-yttrium oxyorthosilicate, cerium doped at industrial sites oral uptake for workers can be regarded as not relevant. Since lutetium-yttrium oxyorthosilicate, cerium doped is also not relevant for any subsequent service life, oral uptake for consumers can be excluded. Against this background and in conformity with ECHA`s principle of avoiding unnecessary animal testing, performance of a study on acute oral toxicity is considered to be not required under Regulation (EC) No 1907/2006 (REACH).[1]: Entry in C&L Inventory Database for lutetium oxide: https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/85136[2]: Entry in C&L Inventory Database for lutetium: https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/13225[3]: Dossier on yttrium oxide, submitted by the registrant: https://echa.europa.eu/registration-dossier/-/registered-dossier/14370/2/1[4]: Dossier on silicon dioxide, submitted by the registrant: https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/2/1/?documentUUID=9cc0c597-f486-41f5-a050-3c0250a8f6e8[5]: Dossier on silicon, submitted by the registrant: https://echa.europa.eu/registration-dossier/-/registered-dossier/16144/2/1/?documentUUID=8a2186b9-0eec-4e50-a843-0ecbba61b36e[6]: Dossier on cerium dioxide, submitted by the registrant: https://echa.europa.eu/registration-dossier/-/registered-dossier/15783/2/1/?documentUUID=cae150e5-978f-4482-930d-cb1a577b7871[7]: Dossier on cerium, submitted by the registrant: https://echa.europa.eu/registration-dossier/-/registered-dossier/1986/2/1
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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