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Short-term toxicity to fish

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short-term toxicity to fish
Type of information:
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
For detailed description on the model and its applicability, see attached QMRF and QPRF document.
Principles of method if other than guideline:
Calculation based on ECOSAR v1.11, Estimation Programs Interface Suite™ for Microsoft® Windows v4.11. US EPA, United States Environmental Protection Agency, Washington, DC, USA
GLP compliance:
Test organisms (species):
other: calculation
Test type:
other: calculation
Water media type:
Key result
96 h
Dose descriptor:
Effect conc.:
4.522 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
other: calculation
Remarks on result:
other: estimate from measured log Kow
The reliable (Q)SAR prediction resulted in a 96-hour LC50 value of 4.522 mg/L.

Description of key information

The acute toxicity of the test item to fish was estimated using ECOSAR v1.11 (EPI Suite v4.11).

The reliable (Q)SAR prediction resulted in a 96-hour LC50 value of 4.522 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
4.522 mg/L

Additional information