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Diss Factsheets
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EC number: 806-451-7 | CAS number: 42532-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- phototransformation in air
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non-GLP, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Indirect photolysis with *OH radical produced from ozone.
- GLP compliance:
- no
- Light source:
- other: Mercury-Xenon
- Details on light source:
- - Lamp: Oriel Instruments UV Lamp, Model 66921 equipped with a 480 W Mercury Xenon bulb
- Emission wavelength spectrum: See Figure 1
- Filters used and their purpose: Manufacturer specifies a transmission range of 200-2500 nm for lamp window. No additional filtration. Some attenuation of IR is expected at quartz window of gas cell. - Duration:
- 47 min
- Temp.:
- 27 °C
- Reference substance:
- yes
- Remarks:
- methane or HFC-125
- DT50:
- 21 yr
- Test condition:
- based on average of four measurements
- Transformation products:
- yes
- Remarks:
- No fluorinated products were detected after reaction.
- Results with reference substance:
- Only fluorinated product detected by GC-MA above 0.015 ppm LOQ. <1% of parent.
- Conclusions:
- The atmospheric lifetime of L-21609 with respect to *OH is 30 years.
- Executive summary:
The atmospheric lifetime of L-21609 with respect to *OH was determined using pentafluoroethane or methane as reference substance in a 10-m FTIR gas cell. Hydroxyl radical was produced by irradiation of ozone in the presence of water vapor. Temperature was 26-28 °C, and pressure was brought to approximately 1 atmosphere with humidified nitrogen. Progress of the reaction was monitored by FTIR spectroscopy according to EPA method 320. Losses of reference substance and L-21609 were <1% due to dark reactions, indicating negligible reaction with ozone or water vapor. In one trial, gas samples taken during the irradiation revealed no increase in volatile fluorinated gas due to photoreaction. Based on the accepted atmospheric lifetimes for HFC-125 (29 y) and methane (12 years), the average atmospheric lifetime of L-21609 with respect to *OH is 30 years.
The study followed sound scientific principles. The study overall was not conducted to GLP criteria. Composition of the reaction mixture is not specified in the report, however the relative reaction rate calculation mitigates the need for this detail. The study assumes phototransformation solely due to hydroxyl radical and does not take direct phototransformation into account. Therefore, this study is classified as reliable with restrictions. It is suitable for entry into a weight of evidence for Risk Assessment, Classification & Labeling, and PBT Analysis.
Concentrations of L-21609 and methane were monitored in the absence of UV/Visible light to assess the background effect of dark reactions (adsorption to or reaction with the cell walls). Less than 1% losses of both L-21609 and reference substance (methane or pentafluoroethane) were observed (Figures 2 - 5). Based on this result L-21609 does not react appreciably with either ozone or water vapor (present at 1000 ppmv) over the duration of this experiment.
On irradiation, linear declines in concentration of ozone, L-21609 and methane were observed for the first 40 minutes of illumination. Regression of this portion of the decay curves produced the following equations:
Run 1:
HFC-125: C/Co = -0.00126 * time + 0.05535, R-sq = 0.988
L-21609: C/Co = -0.00114 * time + 0.03118, R-sq = 0.868
k(L-21609)/k(HFC-125) = 0.90
lifetime( L-21609) = k(L-21609)/k(HFC-125) * lifetime(HFC-125 [28.2y]) = 31y
Run 2:
methane: C/Co = -0.00469 * time + 0.19135, R-sq = 0.98
L-21609: C/Co = -0.00144 * time + 0.04448, R-sq = 0.98
k(L-21609)/k(methane) = 0.31
lifetime (L-21609) = k(L-21609)/k(methane) * lifetime (methane [11.2y]) = 36y
Run 3:
methane: C/Co = -0.00454 * time + 0.16351, R-sq = 0.95
L-21609: C/Co = -0.00167 * time + 0.04313, R-sq = 0.76
k(L-21609)/k(methane) = 0.37
lifetime (L-21609) = 30y
Run 3:
methane: C/Co = -0.00497 * time + 0.40467, R-sq = 0.992
L-21609: C/Co = -0.00251 * time + 0.16037, R-sq = 0.96
k(L-21609)/k(methane) = 0.51
lifetime (L-21609) = 22y
The average atmospheric lifetime of L-21609 is 30 years.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- IR spectrum obtained according to EPA method 320, integrated according to Hodnebrog et al (2013) (Rev. Geophys., 51, 300-378) and used to estimate Global warming potential according to IPCC methods.
- GLP compliance:
- no
- Type of study / information:
- Infrared spectrum, global warming potential
Test material
- Reference substance name:
- C4 F-isonitrile
- IUPAC Name:
- C4 F-isonitrile
- Test material form:
- other: gas
- Details on test material:
- - Name of test material (as cited in study report): L-21609
- Substance type: Mono-constituent
- Physical state: gas
- Storage condition of test material: as a pressurized liquid
Constituent 1
Results and discussion
Any other information on results incl. tables
See attachment for IR spectrum of C4 F-isonitrile. The corrected radiative forcing is 0.225 W∙m-2∙ppbV-1. Assuming an atmospheric lifetime of 30 years, the 100-year GWP of C4 F-isonitrile is 2100.
Applicant's summary and conclusion
- Conclusions:
- The 100-year GWP of C4 F-isonitrile is 2100
- Executive summary:
Potential effects of C4 F-isonitrile on climate were addressed by calculation of 100-year integrated global warming potential (100-year GWP). A high-resolution infrared spectrum was taken using a protocol following EPA method 320. Integrated IR cross-section and radiative forcing were calculated using the approach of Hodnebrog et al. (Rev. Geophys. 51, 300-378). Atmospheric lifetime was determined in this study to be 30 years (reported elsewhere in this dossier). GWP was calculated for this study summary as per IPCC AR5 (2013). The integrated instantaneous radiative forcing was 0.225 W∙m-2∙ppbV-1. The 100-year GWP is 2100.
No testing guideline has been promulgated to determine global warming potential. However, the infrared cross-section data were collected according EPA method 320, and the radiative forcing and GWP were calculated by methods accepted by IPCC. Therefore, this study is classified as reliable without restrictions
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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