Registration Dossier
Registration Dossier
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EC number: 848-536-1 | CAS number: 28911-49-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020-03-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- 440/2008/EC, 30 May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.9
- Temp.:
- 20 °C
- pH:
- 6.28
- Conclusions:
- The log Pow was determined based on the solubility of the test item in water and n-octanol to be > 6.9.
- Executive summary:
A study was conducted according to Regulation EC No. 440/2008, Method A.8 and OECD Guideline 107.During the development of an analytical method the test item showed no UV-activity. Therefore, the log Pow was estimated based on the solubility in water and n-octanol.The log Pow was estimated to be > 6.9.
Reference
The preliminary test at room temperature showed that the octanol solubility of the test item was > 4258 g/L. With the value of the water solubility estimated in study CSL-20-0078.04 (< 0.55 mg/L) and the estimated solubility in octanol from this preliminary test, the partition coefficient Pow can be calculated to be > 6.9. For this range of the partition coefficient the slow stirring method would be the suitable method for the determination. Due to the extremely low water solubility and the low UV-activity of the test item, analytics by the means of HPLC could not be carried out and the test was terminated after the preliminary test.
Description of key information
The log Pow was determined based on the solubility of the test item in water and n-octanol to be > 6.9.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.9
- at the temperature of:
- 20 °C
Additional information
A study was conducted according to Regulation EC No. 440/2008, Method A.8 and OECD Guideline 107. During the development of an analytical method the test item showed no UV-activity. Therefore, the log Pow was estimated based on the solubility in water and n-octanol.The log Pow was estimated to be > 6.9.
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