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EC number: 836-437-6 | CAS number: 577978-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 190-021 February 2020
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- Because the test item is poorly soluble in water, test item stock solution was prepared using a saturated solution method according to the Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures, OECD No. 23.
Saturated test item solution (nominal loading rate of 100.0 mg/L) was prepared by dispersing/dissolving the amount of test item into the test medium (ISO Medium) two days before the start of the experiment. This solution was shaken for about 24 hours at approximately 30°C and then equilibrated for about 24 hours at approximately 20°C.
The non-dissolved test material was removed by filtration through a fine (0.22 μm) filter to give the appropriate 100 % saturated solution.
Test item solution was prepared fresh for each renewal using the method described above. The test solution was prepared just before introduction of the Daphnia (start of the treatments). - Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- The reconstituted water (ISO medium) had a total hardness of 247 mg/L (as CaCO3).
- Test temperature:
- The test temperature was in the range of 20.6 – 20.8°C measured in the test vessels.
- pH:
- The pH was measured at the start and at the end of the renewal periods in one test vessel both in the control and test item group and was in the range of 7.72 – 7.98.
- Dissolved oxygen:
- The dissolved oxygen concentration was measured in the control and in the test concentration in one replicate at the start and at the end of the renewal periods and was in the range of 7.6 – 8.6 mg/L.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 >100 mg/L based on nominal loading rate. The measured concentration was below the limit of quantification.
- Executive summary:
Acute toxicity of CAS 577978-76-8 on Daphnia magna was assessed in an acute immobilisation test, over an exposure period of 48 hours in a semi-static test system following the OECD 202 test guideline in accordinace with GLP.
Because no toxic response was observed during the preliminary range-finding test, a Limit Test was carried out using only one test concentration at 100 mg/L nominal loading rate and one control group in the definitive test.
The test concentration was analytically determined at the start and at the end of the renewal periods, but the test item concentration could not be analytically quantified during the whole experiment, consequently, the measured concentrations were below the Limit of Quantification (LOQ = 0.484 mg/L).
The biological results are based on nominal loading rate.
The 48 hr LC50 is >100 mg/l.
Reference
Description of key information
Acute toxicity of CAS 577978-76-8 on Daphnia magna was assessed in an acute immobilisation test, over an exposure period of 48 hours in a semi-static test system following the OECD 202 test guideline in accordinace with GLP.
Because no toxic response was observed during the preliminary range-finding test, a Limit Test was carried out using only one test concentration at 100 mg/L nominal loading rate and one control group in the definitive test.
The test concentration was analytically determined at the start and at the end of the renewal periods, but the test item concentration could not be analytically quantified during the whole experiment, consequently, the measured concentrations were below the Limit of Quantification (LOQ = 0.484 mg/L).
The biological results are based on nominal loading rate.
The 48 hr LC50 is >100 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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