Amines, N-C10-16-alkyltrimethylenedi-, reaction products with chloroacetic acid

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Generally accepted method

Qualifier:

no guideline followed

Principles of method if other than guideline:

The substance Amines, N-C10-16-alkyltrimethylenedi-, reaction products with chloroacetic acid (20% a.i.), constituting an aqueous solution of the pure active substance, was freeze-dried and the mass of the residue determined gravimetrically

GLP compliance:

yes

Type of method:

other: no specific method

Key result

Water solubility:

> 208 g/L

Temp.:

20 °C

pH:

>= 4 - <= 9

An aqueous solution of test substance (approximately 20%; colourless to slightly yellow) was weighed, freeze dried and then reweighed. The non-aqueous component of the solution was found to be 20.83% by weight and the solubility was concluded to be >20.83% (w/w). The pH dependence of the water solubility was checked by adjusting three solutions of test substance to pH 4.0, 7.0 and 9.0. At pH 4 and 7 the solution appeared clear. At pH 9 the solution appeared viscous and foamy and appeared clear after several hours. It was concluded the solubility of test substance was not pH dependent over the range tested. Amines, N-C10-16-alkyltrimethylenedi-, reaction products with chloroacetic acid (20% a.i.) remained a clear solution regardless of the pH range tested.

Conclusions:

Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of Amines, N-C10-16-alkyltrimethylenedi-, reaction products with chloroacetic acid was determined to be > 20.83% (w/w), corresponding to > 208 g/L (pH 4, 7, 9).

Executive summary:

Amines, N-C10-16-alkyltrimethylenedi-, reaction products with chloroacetic acid (20% a.i.), constituting an aqueous solution of the pure active substance, was freeze-dried and the mass of the residue determined gravimetrically.

The water solubility was determined to be > 20.83% (w/w), corresponding to > 208 g/L.

The pH dependence of the water solubility was checked by adjusting three solutions of test substance to pH 4.0, 7.0 and 9.0. At pH 4 and 7 the solution appeared clear. At pH 9 the solution appeared viscous and foamy and appeared clear after several hours. It was concluded the solubility of test substance was not pH dependent over the range tested. Amines, N-C10-16-alkyltrimethylenedi-, reaction products with chloroacetic acid (20% a.i.) remained a clear solution regardless of the pH range tested.

In view of the fact that the active substance as manufactured constitutes an aqueous solution as a “product by process”, the chosen method is considered to be fully justified.

Description of key information

>208 g/L (gravimetrical determination after freeze-drying, non-guideline method; GLP)

Key value for chemical safety assessment

Water solubility:

208 g/L

at the temperature of:

20 °C

Additional information

Amines, N-C10-16-alkyltrimethylenedi-, reaction products with chloroacetic acid (20% a.i.), constituting an aqueous solution of the pure active substance, was freeze-dried and the mass of the residue determined gravimetrically. The water solubility was determined to be > 20.83% (w/w), corresponding to > 208 g/L.

Although the available study was not conducted according to guideline EEC A.6, it is nevertheless established without reasonable doubt that the substance is soluble in water at concentrations of at least 200 g/L. Determination of a more accurate figure would be entirely immaterial for the risk assessment. Thus, the conduct of a water-solubility study following EEC A.6 would not provide a relevant contribution to the existing knowledge and is therefore considered to be scientifically unjustified.