1-(3,5-Dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone

Skin irritation / corrosion

Administrative data

Endpoint:

skin corrosion: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 430 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER))

Deviations:

no

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

EC Number:

829-719-5

Cas Number:

1190865-44-1

Molecular formula:

C8H2Cl2F4O

IUPAC Name:

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

Test material form:

liquid

In vitro test system

Test system:

isolated skin discs

Source species:

rat

Cell type:

non-transformed keratinocytes

Cell source:

other: pelt of humanely killed young Wistar strain rat

Source strain:

Wistar

Details on animal used as source of test system:

Not available

Vehicle:

unchanged (no vehicle)

Control samples:

yes, concurrent negative control

yes, concurrent positive control

Amount/concentration applied:

Not reported

Duration of treatment / exposure:

24 hours

Number of replicates:

Three

Results and discussion

In vitro

Results

Irritation / corrosion parameter:

transcutaneous electrical resistance (in kΩ)

Run / experiment:

Mean

Value:

22.7

Vehicle controls validity:

not applicable

Negative controls validity:

valid

Remarks:

13.4

Positive controls validity:

valid

Remarks:

0.97

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the results of the in vitro TER study, the substance is unlikely to be corrosive to skin in vivo.

Executive summary:

An in vitro skin corrosion study following the principles of OECD TG 430 (transcutaneous electrical resistance assay) was conducted with the substance under non-GLP conditions. Due to the poor level of documentation, the reliability of the test cannot be assessed. Skin discs were prepared from the pelt of a humanely killed young Wistar strain rat. Three discs were used to test the corrosion potential of the test substance, a negative and a positive control. All substances were applied as such to the surfaces of the skin discs for a period of 24 hours, and then removed with a jet of warm water. The electrical resistance of the skin was then measured. The mean electrical resistance measured was 22.7 kOhms for the test substance, 13.4 kOhms for the negative control and 0.97 kOhms for the positive control. Based on these results, the substance is considered unlikely to be corrosive to the skin in vivo.