Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 122 (Determination of pH, Acidity and Alkalinity)
Version / remarks:
2013
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one
EC Number:
829-719-5
Cas Number:
1190865-44-1
Molecular formula:
C8H2Cl2F4O
IUPAC Name:
1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one
Test material form:
liquid

Reagents

Reagent:
water

Results and discussion

pH value
Key result
pH value:
6.13
Temp.:
20 °C
Concentration:
1 other: % w/v

Any other information on results incl. tables

Table 1: pH value determinations

Determination

pH value

Overall mean pH

Reading after 1 minute

Reading after 2 minutes

Reading after 10 minutes

1

6.91

6.62

6.24

6.13

2

6.95

6.63

6.02

Applicant's summary and conclusion

Conclusions:
The pH value of a 1% w/v aqueous dispersion of the test substance was determined to be 6.13 at 20 °C.
Executive summary:

The pH value of the test substance was determined under GLP in accordance with OECD TG 122. A pH meter was confirmed to be accurately calibrated by using certified reference buffer solutions that were pre-equilibrated at 20 °C. Appropriate aliquots of test substance were diluted in high purity water to achieve a 1% w/v aqueous dispersion. The water was pre-equilibrated to 20 °C before use. The pH value was recorded after a period of one minute and a second reading was done after after two minutes. As the difference between the two readings was >0.1 pH units, a final reading was done after 10 minutes. The pH value determined in two independent tests was 6.24 and 6.02, respectively. The average pH value was 6.13 at 20 °C.