Registration Dossier

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: QSAR-tool
Title:
Estimation Program Interface EPI Suite (TM) v4.11: BIOWIN (v4.10)
Author:
United States Environmental Protection Agency, Washington, DC, USA.
Bibliographic source:
http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm

Materials and methods

Principles of method if other than guideline:
BIOWIN contains seven separate models. Version 4.10 designates these models as follows:
Probability of Rapid Biodegradation:
Biowin1: linear regression probability model
Biowin2: nonlinear regression probability model
Expert Survey Biodegradation:
Biowin3: expert survey ultimate biodegradation model
Biowin4: expert survey primary biodegradation model
MITI* Biodegradation Probability:
Biowin5: MITI linear regression model
Biowin6: MITI nonlinear regression model
Anaerobic Biodegradation Probability
Biowin7: anaerobic biodegradation model
GLP compliance:
no

Results and discussion

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Interpretation of results:
not readily biodegradable