Registration Dossier
Registration Dossier
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EC number: 609-099-0 | CAS number: 352303-67-4
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 6th - August 14th 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- (2-fluoro-3-methoxyphenyl)boronic acid
- EC Number:
- 609-099-0
- Cas Number:
- 352303-67-4
- Molecular formula:
- FC6H3(OCH3)B(OH)2
- IUPAC Name:
- (2-fluoro-3-methoxyphenyl)boronic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Purity: 100.2%
Batch No.: 18051400
Expiration date: March 14, 2019
Physical status: Off-white solid
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.14
- Remarks on result:
- other: Temp and pH not stated (column temp 30 C)
- Key result
- Type:
- Pow
- Partition coefficient:
- 13.8
- Remarks on result:
- other: Temp and pH not stated (column temp 30 C)
- Details on results:
- Temp and pH not stated (column temp 30 C)
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient (n-octanol/water) of FMPBA was determined compatible with the Principles of OECD guidelines for testing chemicals No. 117 'Partition Coefficient (m-octanol/water), HIgh Performance Liquid Chromatography (HPLC) Method'. Based on the test results the Pow of FMPBA was 13.8, lgPow was 1.14.
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