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EC number: 620-249-4 | CAS number: 39075-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 May to 19 June 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 3,5-dimethoxy-4-propoxybenzaldehyde
- EC Number:
- 620-249-4
- Cas Number:
- 39075-26-8
- Molecular formula:
- C12 H16 O4
- IUPAC Name:
- 3,5-dimethoxy-4-propoxybenzaldehyde
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): v59442
- Molecular formula (if other than submission substance):
- Physical state: light yellow brown solid
- Analytical purity: > 94%
- Lot/batch No.: v59442/F2A
- Expiration date of the lot/batch: 01 May 2008
- Storage condition of test material: at room temperature in the dark
- Other: melting at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sultzfeld, Germany
- Age at study initiation: ca 10 weeks
- Weight at study initiation: 195-229 g
- Fasting period before study: 20 hours (+ 3-4 hours after administration of the substance)
- Housing: 3 animals in Macrolon cages (MIV type height 11 cm) with sterilised sawdust bedding material and paper as cage enrichment
- Diet: pelleted rodent diet (SM R/M-Z, SNIFF Spezialdiäten, Soest, Germany) ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.0-22.7°C
- Humidity (%): 39-83%
- Air changes (per hr): ca. 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.742 mL
DOSAGE PREPARATION (if unusual): The substance was heated in a water bath at maximum 39 °C during maximum 30 minutes
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: not indicated - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 females/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: clinical signs on periodic intervals during day 1 and daily thereafter
- Frequency of weighing: on day 1 (before treatment), 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopy - Statistics:
- NA
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 female at first trial at 2000 mg/kg bw on day 1
none at the second trial at 2000 mg/kg bw - Clinical signs:
- other: tremor, hunched posture and/or uncoordinated movements on day 1 and 2 in surviving animals. clonic spasms, tremor, ventro-lateral recumbency, pale appearance and shallow respiration in the female that died
- Gross pathology:
- no findings
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the substance is > 2000 mg/kg bw
- Executive summary:
The substance was tested with the acute toxic class method in female rats (3/group) treated at 2000 mg/kg bw. In the first trial 1 female died on day 1. In the second trial no mortality was observed. Clinical signs in surviving animals consisted of tremor, hunched posture and/or uncoordinated movements (day 1 and 2). No effects on bodyweight and no macroscopic abnormalites were found. The LD50 is > 2000 mg/kg bw.
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