Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 11 OCTOBER 2018 to 6 NOVEMBER 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
differential scanning calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
>= 152.04 - <= 181.94 °C
Decomposition:
no
Decomp. temp.:
ca. 260.53 °C
Sublimation:
no

Applicant's summary and conclusion

Conclusions:
The melting point and melting point should have been determined via DSC (differential
scanning calorimetry).
Three DSC measurements were performed. In all measurements two endothermic peaks
which came directly after each other and one exothermic behaviour were detected.
The test item consists of two function groups (isopropylamino and antraquinone), the two
endothermic peaks could be the melting process of the test item. The melting point will be
given in a range with two peak maxima. The beginning and the end of the process were
evaluated with the event marker.
Based on observations of the pre-tests also the appearance of the test item in the crucible
after DSC measurement the exothermic behaviour should be identified as decomposition.
The beginning of the decomposition was evaluated with the event marker function with
260.53 °C (533.68 K).
Melting point:
The melting point is given in a range from: 152.04 °C to 181.94 °C (425.19 K to 455.09 K)
with
the first peak maximum of 170.31 °C (443.46 K) and
the second peak maximum of 176.77 °C (449.92 K)
These values represent the three independent determinations.