(R)-5-bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole

Guidance on Safe Use

First-aid measures

Description of First Aid Measures

Eye Contact: Flush with water while holding eyelids open for at least 15 minutes. Seek medical attention

immediately.

Skin Contact: Remove contaminated clothing. Flush area with large amounts of water. Use soap. Seek

medical attention.

Ingestion: Never give anything by mouth to an unconscious person. Wash out mouth with water. Do not induce vomiting unless directed by medical personnel. Seek medical attention immediately.

Inhalation: Remove to fresh air and keep patient at rest. Seek medical attention immediately.

Fire-fighting measures

Extinguishing Media: Extinguish fires with CO2, extinguishing powder, foam, or water.

Special Hazards Arising from the Substance or Mixture:

Hazardous CombustionProducts: Formation of toxic gases is possible during heating or fire.

Fire / Explosion Hazards: Fine particles (such as dust and mists) may fuel fires/explosions. High sensitivity of a dust

cloud to ignition, based on minimum ignition energy.

Advice for Fire-Fighters

During all fire fighting activities, wear appropriate protective equipment, including self-contained breathing apparatus

Accidental release measures

Personal Precautions, Protective Equipment and Emergency Procedures:

Personnel involved in clean-up should wear appropriate personal protective equipment.

Minimize exposure.

Environmental Precautions

Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release.

Methods and Material for Containment and Cleaning Up

Measures for Cleaning /Collecting:

Contain the source of the spill if it is safe to do so. Collect spilled material by a method that

controls dust generation. Avoid use of a filtered vacuum to clean spills of dry solids, due to the

potential for electrostatic discharge and high sensitivity to ignition.

Additional Consideration forLarge Spills:

Non-essential personnel should be evacuated from affected area. Report emergency

situations immediately. Clean up operations should only be undertaken by trained personnel.

Handling and storage

Precautions for Safe Handling

Ground and bond all bulk transfer equipment. All conductive elements of the system that contact the dry substance should be

properly bonded and grounded and equipped with proper explosion relief or suppression systems. This material should not be

flowed through nonconductive ducts or pipes because of the potential for electrostatic discharge ignition. Restricting the use of

high resistivity materials, such as plastics, should be considered. Avoid open handling. Minimize dust generation. Use local

exhaust ventilation or perform work under fume hood/fume cupboard. Avoid inhalation and contact with skin, eye, and clothing.

When handling, use appropriate personal protective equipment. Wash hands and any exposed skin after removal

of PPE. Releases to the environment should be avoided. Review and implement appropriate technical and procedural waste

water and waste disposal measures to prevent occupational exposure or environmental releases. Potential points of process

emissions of this material to the atmosphere should be controlled with dust collectors, HEPA filtration systems or other equivalent

controls.

Conditions for Safe Storage, Including any Incompatibilities

Storage Conditions: Store at room temperature in properly labeled containers. Keep away from heat, sparks and flames.

Incompatible Materials: Avoid contacts with acids. As a precautionary measure, keep away from strong oxidizers

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 2811

Shipping information

Proper shipping name and description:

Toxic solid, organic, n.o.s. (Eletriptan)

Chemical name:

Eletriptan

Language:

English

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN 2811

Shipping information

Proper shipping name and description:

Toxic solid, organic, n.o.s. (Eletriptan)

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN 2811

Shipping information

Proper shipping name and description:

Toxic solid, organic, n.o.s. (Eletriptan)

Marine pollutant

Special provisions / remarks

Remarks:

Environmental Hazard(s): Marine Pollutant

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN 2811

Shipping information

Proper shipping name and description:

Toxic solid, organic, n.o.s. (Eletriptan)

Chemical name:

Eletriptan

Remarks

SpecialProvisions

Exposure controls / personal protection

Exposure Controls

Engineering Controls: Engineering controls should be used as the primary means to control exposures. Use process

containment, local exhaust ventilation, or other engineering controls to maintain airborne levels

within the OEB range.

Personal Protective Equipment:

Refer to applicable national standards and regulations in the selection and use of personal

protective equipment (PPE).

Hands: Wear impervious gloves, (e.g. Nitrile, etc.) to prevent skin contact.  (Protective gloves must meet the standards in accordance with EN374, ASTM F1001 or international equivalent.)

Eyes: Face shield or goggles Avoid all hand to eye contact until gloves have been removed and hands washed.Wear safety glasses as minimumprotection. (Safety glasses must meet the standards in accordance with EN166 or international equivalent.)

Skin: Wear impervious protective clothing to prevent skin contact - consider use of disposable if clothing where appropriate.(Protective clothing must meet the standards in accordance with EN13982 or international equivalent.)

Respiratory protection: Under normal conditions of use, if the applicable Occupational Exposure Limit (OEL) is exceeded, wear an appropriate respirator with a protection factor sufficient to control exposures to below the OEL (e.g. particulate respirator with a full mask, P3 filter).  (Respirators must meet the standards in accordance with EN136, EN143 or international equivalent.)

Stability and reactivity

Reactivity: No data available

Chemical Stability: Stable under normal conditions of use.

Possibility of Hazardous Reactions

Oxidizing Properties: No data available

Conditions to Avoid: Fine particles (such as dust and mists) may fuel fires/explosions.

Incompatible Materials: Avoid contacts with acids. As a precautionary measure, keep away from strong oxidizers

Hazardous Decomposition Products: None expected under normal conditions.

Disposal considerations

Waste Treatment Methods:

Dispose of waste in accordance with all applicable laws and regulations. Member State specific and Community specific provisions must be considered. Considering the relevant known environmental and human health hazards of the material, review and implement appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure and environmental release. It is recommended that waste minimization be practiced. The best available technology should be utilized to prevent environmental releases. This may include destructive techniques for waste and wastewater.