Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
explosiveness, other
Remarks:
Thermal stability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 September - 30 October 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 113 (1981) Screening Test for Thermal Stability and Stability in Air
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(aminocarbonyl)-1-ß-D-ribofuranosyl-pyridinium bromide
Cas Number:
78687-39-5
Molecular formula:
C11H15BrN2O5
IUPAC Name:
3-(aminocarbonyl)-1-ß-D-ribofuranosyl-pyridinium bromide
impurity 1
Chemical structure
Reference substance name:
Nicotinamide
EC Number:
202-713-4
EC Name:
Nicotinamide
Cas Number:
98-92-0
Molecular formula:
C6H6N2O
IUPAC Name:
nicotinamide
impurity 2
Chemical structure
Reference substance name:
Methanol
EC Number:
200-659-6
EC Name:
Methanol
Cas Number:
67-56-1
Molecular formula:
CH4O
IUPAC Name:
methanol
impurity 3
Chemical structure
Reference substance name:
Ethyl acetate
EC Number:
205-500-4
EC Name:
Ethyl acetate
Cas Number:
141-78-6
Molecular formula:
C4H8O2
IUPAC Name:
ethyl acetate
impurity 4
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
impurity 5
Reference substance name:
inorganic salts by sulphated ash
IUPAC Name:
inorganic salts by sulphated ash
impurity 6
Chemical structure
Reference substance name:
Bromic acid
EC Number:
232-158-3
EC Name:
Bromic acid
Cas Number:
7789-31-3
Molecular formula:
BrHO3
IUPAC Name:
bromic acid
impurity 7
Reference substance name:
Unknown impurities.
Molecular formula:
Not available as unknown impurities.
IUPAC Name:
Unknown impurities.
Test material form:
solid
Details on test material:
Batch / Lot No. 1000146/01
Specific details on test material used for the study:
Batch No.: 1000146/01
Storage Conditions: Freezer (approx. -15 °C)

Results and discussion

Small-scale preliminary tests
Parameter:
other: Exothermal decomposition energy
Remarks on result:
other: The exothermic decomposition energy was <-500 J/g

Any other information on results incl. tables

The test item showed a first endothermic effect in the temperature range of 100-120°C. This endothermic effect is directly followed by an exothermic effect in the temperature range of 120-140°C with an average energy release of -50 J/g. A second exothermic effect was observed in the temperature range of 140-250°C with an average energy release of -210 J/g. A third exothermic effect was observed in the temperature range of 290-470°C with an average energy released of -160 J/g.

Results of the DSC-measurements

No.

Sample weight / mg

Start of effect / °C

Energy[1]/ (J/g)

Remark

PN18330

6.33

100
120
140
290

+60 (endothermic)
-40 (exothermic)
-190 (exothermic)
-200 (exothermic)

Figure 3

PN18381

7.64

100
120
140
290

+60 (endothermic)
-50 (exothermic)
-230 (exothermic)
-120 (exothermic)

Figure 4

In the DSC measurement the energy of the exothermic decomposition of the test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687 -39 -5) was <-500 J/g. Therefore, further tests on explosive properties don't need to be performed and the test item should not be classified as explosive substance in class 1 according th the UN Transport Regulation or to the GHS or CLP Regulation EC 1272/2008 Annex 1: 2.1.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the DSC measurement the energy of the exothermic decomposition of the test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) was <-500 J/g. Therefore, further tests on explosive properties had not to be performed. According to the results, the test item should not be classified as explosive substance in class 1 according to the UN Transport Regulation or according to the GHS or CLP Regulation EC 1272/2008 Annex 1: 2.1.
Executive summary:

Based on the DSC measurement the energy of the exothermic decomposition of the test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) was <-500 J/g. Therefore, further tests on explosive properties had not to be performed. According to the results, the test item should not be classified as explosive substance in class 1 according to the UN Transport Regulation or according to the GHS or CLP Regulation EC 1272/2008 Annex 1: 2.1.