Registration Dossier
Registration Dossier
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EC number: 278-636-5 | CAS number: 77182-82-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Glufosinate ammonium was tested in a wide range of in vitro tests including an Ames test on four strains of Salmonella typhimurium (TA98, TA100, TA1335 and TA1537) and one Escherichia coli (WP2 uvrA), a gene conversion DNA repair test at the "Ade 2" and "Trp 5" loci on different chromosomes of the Saccharomyces cervisiae cell, a forward gene mutation assay in 5 different genes of the Schizosaccharomyces pombe cell, an in vitro chromosome aberration test in cultured human lymphocytes, an HPRT test in Chinese hamster cell line V79 and a rat primary hepatocyte unscheduled DNA synthesis assay and an in vivo micronucleus test in NMRI mice. In all these tests, glufosinate ammonium did not induce any mutagenic effects in presence or absence of metabolic activation.
Justification for classification or non-classification
In all genotoxicity tests available, glufosinate ammonium did not induce any mutagenic effects in presence or absence of metabolic activation. Therefore, classification according to Regulation (EC) 1272/2008 is not warranted.
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