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EC number: 479-660-0
CAS number: -
Acute toxicity after single oral application was tested in female rats,
which received 2000 mg/kg bw (2 x 3 females). All animals survived until
the end of the study without showing any signs of toxicity. Throughout
the 14-day observation period, the body weight gain of the test animals
was within the normal range of variation for this strain. At necropsy,
no macroscopic findings were observed. The LD50 value for acute oral
toxicity is > 2000 mg/kg bw.
A single dermal application of the test item to 10 rats (5 males and 5
females) at a dose of 2000 mg/kg bw was associated with no mortality and
neither clinical signs. The dermal LD50 was determined to be > 2000
The studies were carried out according to OECD guidelines 423 and 402.
Acute oral testing of the test item in famels rat yielded a LD50 greater
than 2000 mg/kg be. After administration of 2000 mg/kg bw neither deaths
nor symptoms occurred. Only the feces was discolored by the test
compound on day 2 of the study. Development of body weight was not
impaired. All animals were killed at the end of the observation period.
They showed no macroscopically visible changes.
The acute dermal toxicity testing of the test item yielded a LD50 > 2000
mg/kg bw in both male and femal animals. After administration of 2000
mg/kg w neither deaths nor symptoms occurred. The male animals showed
reddish discolored akin one day after treatment when the bandage was
removed. Females showed reddish discolored skin on day 1 and 2 after
treatment. Development of body weight was not impaired in male animals.
One of five females showed a slight body weigth loss in the first study
week, but body weight gain normalised in the second study week. No
animal showed macroscopically visible changes.
to the results described in the acute oral and dermal toxicity studies
(LD50oral/dermal in rats > 2000 mg/kg bw) the substance does
not have to be classified as acute toxic.
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